Saltiel A R, Sorbara-Cazan L R
Laboratory of Biochemical Endocrinology, Rockefeller University, New York, New York 10021-6399.
Biochem Biophys Res Commun. 1987 Dec 31;149(3):1084-92. doi: 10.1016/0006-291x(87)90519-5.
Some of the actions of insulin may be mediated by the intracellular generation of an inositol phosphate glycan that modulates the activities of certain metabolic enzymes. The actions of this molecule were evaluated on glucose utilization in intact rat adipocytes. The inositol glycan led to the dose-dependent stimulation of glucose oxidation and lipogenesis. The extent of stimulation was similar to that observed for insulin. The stimulation of lipogenesis was seen only at high concentrations of glucose, suggesting regulation of processes distal to glucose uptake. The effects of the inositol glycan on intact adipocytes were specifically attenuated with inositol monophosphate in a dose dependent manner. These results further support a role for this substance as a second messenger for some of the actions of insulin, and indicate that the cellular uptake of the inositol glycan may occur by a specific transport system.
胰岛素的某些作用可能是由细胞内生成的一种肌醇磷酸聚糖介导的，该聚糖可调节某些代谢酶的活性。在完整的大鼠脂肪细胞中评估了这种分子对葡萄糖利用的作用。肌醇聚糖导致葡萄糖氧化和脂肪生成呈剂量依赖性刺激。刺激程度与胰岛素观察到的相似。脂肪生成的刺激仅在高浓度葡萄糖时出现，提示对葡萄糖摄取远端过程的调节。肌醇聚糖对完整脂肪细胞的作用被单磷酸肌醇以剂量依赖性方式特异性减弱。这些结果进一步支持了该物质作为胰岛素某些作用的第二信使的作用，并表明肌醇聚糖的细胞摄取可能通过特定的转运系统发生。
