Laboratory of Veterinary Clinical Oncology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
Laboratory of Veterinary Clinical Oncology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
J Comp Pathol. 2020 Oct;180:9-15. doi: 10.1016/j.jcpa.2020.08.005. Epub 2020 Sep 9.
The hearts of three dogs, clinically diagnosed as having persistent atrial standstill syndrome (PAS), were studied post mortem. The most significant gross findings in the hearts of all three dogs were dilatation and marked reduction in the thickness of both atrial walls. Histopathologically, all three had widespread progressive loss of the atrial myocardium with replacement by fatty or fibrofatty tissue, consistent with atrial myopathy. The lesion mainly affected the upper half of both atria and was more severe in the epimyocardium and midmyocardium than in the endomyocardium. On the basis of these observations, it is proposed that the atrial myopathy commences in the upper regions of both atria and progresses downwards, as has been demonstrated electrophysiologically in PAS in humans, and extends from the epicardium towards the endocardium.
对 3 只临床诊断为持久性房性静止综合征（PAS）的狗的心脏进行了死后研究。这 3 只狗的心脏中最显著的大体发现是扩张和心房壁明显变薄。组织病理学上，所有 3 只狗都有广泛的进行性心房心肌丧失，被脂肪或纤维脂肪组织取代，符合心房肌病。病变主要影响左右心房的上半部分，心外膜和中膜比心内膜更严重。基于这些观察结果，有人提出心房肌病始于左右心房的上部区域，并向下进展，这与人类 PAS 的电生理学研究结果一致，并从心外膜向心内膜延伸。
