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1
The role of H-2 and Ia antigens in graft-versus-host reactions (GVHR). Presence of host alloantigens on donor cells after GVHR and suppression of GVHR with an anti-Ia antiserum against hose Ia antigens.H-2和Ia抗原在移植物抗宿主反应（GVHR）中的作用。GVHR后供体细胞上宿主同种异体抗原的存在以及用针对宿主Ia抗原的抗Ia抗血清对GVHR的抑制。
J Exp Med. 1979 Jan 1;149(1):137-49. doi: 10.1084/jem.149.1.137.
2
Role of Ia antigens in graft vs. host reactions. II. Molecular and functional analysis of T cell alloreactivity by the characterization of host Ia antigens on alloactivated donor T cells.Ia抗原在移植物抗宿主反应中的作用。II. 通过对同种异体激活的供体T细胞上宿主Ia抗原的表征进行T细胞同种异体反应性的分子和功能分析。
J Exp Med. 1982 Jan 1;155(1):61-82. doi: 10.1084/jem.155.1.61.
3
GVHR elicited by products of class I or class II loci of the MHC: analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GVHR-induced mortality, medullary aplasia, and enteropathy.由主要组织相容性复合体（MHC）I类或II类基因座产物引发的移植物抗宿主反应（GVHR）：分析小鼠T淋巴细胞对MHC I类和II类基因座产物的反应与GVHR诱导的死亡率、骨髓发育不全和肠病的相关性。
J Immunol. 1985 Sep;135(3):1637-43.
4
Role of L3T4+ and Lyt-2+ donor cells in graft-versus-host immune deficiency induced across a class I, class II, or whole H-2 difference.L3T4+和Lyt-2+供体细胞在跨越I类、II类或整个H-2差异诱导的移植物抗宿主免疫缺陷中的作用。
J Immunol. 1988 Apr 15;140(8):2600-8.
5
Modulation of F1 cytotoxic potentials by graft-vs-host reaction. Cooperative non-H-2- and H-2D region-gene control of F1 natural resistance to graft-vs-host reaction-associated immunosuppression.移植物抗宿主反应对F1细胞毒性潜能的调节。F1对移植物抗宿主反应相关免疫抑制的天然抗性的非H-2和H-2D区域基因协同控制。
J Immunol. 1989 Mar 1;142(5):1495-9.
6
Modulation of F1 cytotoxic potentials by GvHR. Host- and donor-derived cytotoxic lymphocytes arise in the unirradiated F1 host spleens under the condition of GvHR-associated immunosuppression.移植物抗宿主反应对F1细胞毒性潜能的调节。在移植物抗宿主反应相关免疫抑制条件下，宿主和供体来源的细胞毒性淋巴细胞在未受照射的F1宿主脾脏中产生。
J Immunol. 1983 Sep;131(3):1142-8.
7
Effect of graft-versus-host reaction on the immune response to alloantigens and growth of a syngeneic tumor.移植物抗宿主反应对同种异体抗原免疫反应及同基因肿瘤生长的影响。
Exp Hematol. 1975 Jan;3(1):12-21.
8
Graft-versus-host reaction-induced immune modulation. I. Donor-recipient genetic disparity and the differential expression of Lyt-2, L3T4, and Ly-6 during acute reactions in the host thymus.移植物抗宿主反应诱导的免疫调节。I. 供体-受体基因差异以及宿主胸腺急性反应期间Lyt-2、L3T4和Ly-6的差异表达。
J Immunol. 1988 Mar 15;140(6):1717-25.
9
Modulation of F1 cytotoxic potentials by GvHR: role and mode of action of non-MHC genes that determine the hybrid resistance to GvHR-associated suppression of F1 cytotoxic potential.移植物抗宿主反应对F1细胞毒性潜能的调节：决定杂种对移植物抗宿主反应相关的F1细胞毒性潜能抑制的杂种抗性的非主要组织相容性复合体基因的作用及作用方式
J Immunol. 1984 May;132(5):2218-25.
10
Alloimmunization-activated suppressor cells. I: Abrogation of lethal graft-versus-host reaction directed against non-H-2 antigens.同种免疫激活的抑制细胞。I：消除针对非H-2抗原的致死性移植物抗宿主反应。
Transplantation. 1983 Jul;36(1):60-8.

引用本文的文献

1
Passive acquisition of leukocyte proteins is associated with changes in phosphorylation of cellular proteins and cell-cell adhesion properties.白细胞蛋白的被动获取与细胞蛋白磷酸化及细胞间黏附特性的变化有关。
Am J Pathol. 1994 Oct;145(4):930-40.
2
Protection against graft vs. host-associated immunosuppression in F1 mice. I. Activation of F1 regulatory cells by host-specific anti-major histocompatibility complex antibodies.F1小鼠中针对移植物抗宿主相关免疫抑制的保护作用。I. 宿主特异性抗主要组织相容性复合体抗体对F1调节细胞的激活
J Exp Med. 1981 Dec 1;154(6):1922-34. doi: 10.1084/jem.154.6.1922.
3
Induction and avoidance of graft-versus-host reactions: a review.移植物抗宿主反应的诱导与避免：综述
J R Soc Med. 1981 Dec;74(12):901-3. doi: 10.1177/014107688107401209.
4
Role of Ia antigens in graft vs. host reactions. II. Molecular and functional analysis of T cell alloreactivity by the characterization of host Ia antigens on alloactivated donor T cells.Ia抗原在移植物抗宿主反应中的作用。II. 通过对同种异体激活的供体T细胞上宿主Ia抗原的表征进行T细胞同种异体反应性的分子和功能分析。
J Exp Med. 1982 Jan 1;155(1):61-82. doi: 10.1084/jem.155.1.61.
5
In vitro analysis of allogeneic lymphocyte interaction. V. Identification and characterization of two components of allogeneic effect factor, one of which displays H-2-restricted helper activity and the other, T cell-growth factor activity.同种异体淋巴细胞相互作用的体外分析。V. 同种异体效应因子两种成分的鉴定与特性，其中一种表现出H-2限制性辅助活性，另一种表现出T细胞生长因子活性。
J Exp Med. 1981 Jan 1;153(1):107-28. doi: 10.1084/jem.153.1.107.
6
Allosuppressor and allohelper T cells in acute and chronic graft-vs-host disease. I. Alloreactive suppressor cells rather than killer T cells appear to be the decisive effector cells in lethal graft-vs.-host disease.急性和慢性移植物抗宿主病中的同种抑制性T细胞和同种辅助性T细胞。I. 在致死性移植物抗宿主病中，起决定性作用的效应细胞似乎是同种反应性抑制细胞而非杀伤性T细胞。
J Exp Med. 1982 May 1;155(5):1501-22. doi: 10.1084/jem.155.5.1501.
7
Graft-vs.-host-associated immune suppression is activated by recognition of allogeneic murine I-A antigens.移植物抗宿主相关的免疫抑制是通过识别同种异体小鼠I-A抗原而激活的。
J Exp Med. 1983 Mar 1;157(3):936-46. doi: 10.1084/jem.157.3.936.
8
Cells bearing Ia antigens in the murine thymus. An ultrastructural study.小鼠胸腺中携带Ia抗原的细胞。一项超微结构研究。
Am J Pathol. 1983 Apr;111(1):88-97.
9
Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells.T细胞库的早期发育。用抗Ia抗体对新生小鼠进行体内治疗会干扰I限制性T细胞的分化，但不会干扰K/D限制性T细胞的分化。
J Exp Med. 1983 Jun 1;157(6):1932-46. doi: 10.1084/jem.157.6.1932.
10
Conversion of immunity to suppression by in vivo administration of I-A subregion-specific antibodies.通过体内给予I-A亚区特异性抗体将免疫转化为抑制。
J Exp Med. 1982 Aug 1;156(2):480-91. doi: 10.1084/jem.156.2.480.

本文引用的文献

1
SYNERGIC AND ANTAGONISTIC EFFECTS OF ISOANTIBODY UPON GRAFT-VERSUS-HOST DISEASE.同种抗体对移植物抗宿主病的协同和拮抗作用
Transplantation. 1965 Mar;3:161-9. doi: 10.1097/00007890-196503000-00004.
2
Graft versus host reactions. Their natural history, and applicability as tools of research.移植物抗宿主反应。其自然史及其作为研究工具的适用性。
Prog Allergy. 1962;6:349-467.
3
Protection against homologous disease in hybrid mice by passive and active immunological enhancement-facilitation.通过被动和主动免疫增强促进作用对杂交小鼠同源疾病的保护。
Transplantation. 1968 Mar;6(2):187-202. doi: 10.1097/00007890-196803000-00005.
4
Incompatible bone-marrow transplantation in lymphopenic immunologic deficiency. Circumvention of fatal graft-versus-host disease by immunologic enhancement.淋巴细胞减少性免疫缺陷中的不相容骨髓移植。通过免疫增强规避致命的移植物抗宿主病。
N Engl J Med. 1971 Nov 4;285(19):1035-42. doi: 10.1056/NEJM197111042851901.
5
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.胸腺来源淋巴细胞上Ia（与H-2相关）抗原表达的证据。
J Exp Med. 1974 Nov 1;140(5):1273-84. doi: 10.1084/jem.140.5.1273.
6
A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells.一种用于检测大鼠淋巴细胞移植物抗宿主活性的淋巴结重量测定法。
Transplantation. 1970 Sep;10(3):258-66. doi: 10.1097/00007890-197009000-00007.
7
Suppression of the graft-versus-host reaction by passive immunization of donor against recipient antigens.通过供体对受体抗原进行被动免疫来抑制移植物抗宿主反应。
Proc Soc Exp Biol Med. 1970 Feb;133(2):651-4. doi: 10.3181/00379727-133-34537.
8
The involvement of LD- and SD-region differences in MLC and CML: a three-cell experiment.MLC和CML中LD区与SD区差异的参与：一项三细胞实验。
Transplant Proc. 1973 Dec;5(4):1651-5.
9
Demonstration by MLR test of a previously unsuspected intra-H-2 crossover in the B10.HTT strain: implications concerning location of MLR determinants in the Ir region.通过混合淋巴细胞反应（MLR）试验证明B10.HTT品系中先前未被怀疑的H-2复合体内交叉：关于MLR决定簇在Ir区域定位的意义。
Transplant Proc. 1973 Dec;5(4):1507-10.
10
Characteristics of disparate histocompatibility barriers in congenic strains of mice. I. Graft-versus-host reactions.小鼠同源近交系中不同组织相容性屏障的特征。I. 移植物抗宿主反应。
Transplantation. 1972 Dec;14(6):761-70. doi: 10.1097/00007890-197212000-00015.

H-2和Ia抗原在移植物抗宿主反应（GVHR）中的作用。GVHR后供体细胞上宿主同种异体抗原的存在以及用针对宿主Ia抗原的抗Ia抗血清对GVHR的抑制。

The role of H-2 and Ia antigens in graft-versus-host reactions (GVHR). Presence of host alloantigens on donor cells after GVHR and suppression of GVHR with an anti-Ia antiserum against hose Ia antigens.

作者信息

Prud'homme G J, Sohn U, Delovitch T L

出版信息

J Exp Med. 1979 Jan 1;149(1):137-49. doi: 10.1084/jem.149.1.137.

DOI:10.1084/jem.149.1.137
PMID:33223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2184751/
Abstract

By using an indirect immunofluorescence technique, the presence of host cell derived H-2K, H-2D, and Ia alloantigens on donor cells recovered from recipient spleens after a graft-versus-host response (GVHR) was demonstrated. Mapping studies indicated that only host K, D, and I-A region gene products could be identified on the donor cells. Host I-E/C- and I-J-subregion products were not absorbed by donor cells. Treatment of activated donor cells with anti-Ly sera plus C' revealed that donor cells carrying host Ia antigens have a Ly-1+,2-,3- phenotype, whereas donor cells carrying H-2K and H-2D host antigens have a Ly-1-,2+,3+ phenotype. A GVHR that resulted from only an I-region incompatibility was suppressed by the injection of recipient mice with an anti-Ia antiserum directed against self Ia antigens. The degree of suppression was proportional to the amount of anti-Ia antiserum administered.

摘要

通过使用间接免疫荧光技术，证实了在移植物抗宿主反应（GVHR）后从受体脾脏中回收的供体细胞上存在宿主细胞衍生的H-2K、H-2D和Ia同种异体抗原。图谱研究表明，在供体细胞上只能鉴定出宿主K、D和I-A区域基因产物。宿主I-E/C-和I-J亚区域产物未被供体细胞吸收。用抗Ly血清加补体（C'）处理活化的供体细胞表明，携带宿主Ia抗原的供体细胞具有Ly-1 +、2 -、3 -表型，而携带H-2K和H-2D宿主抗原的供体细胞具有Ly-1 -、2 +、3 +表型。仅由I区域不相容性导致的GVHR可通过给受体小鼠注射针对自身Ia抗原的抗Ia抗血清来抑制。抑制程度与所给予的抗Ia抗血清量成正比。