胸腺来源淋巴细胞上Ia（与H-2相关）抗原表达的证据。
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.
作者信息
Frelinger J A, Neiderhuber J E, David C S, Shreffler D C
出版信息
J Exp Med. 1974 Nov 1;140(5):1273-84. doi: 10.1084/jem.140.5.1273.
Abstract
We have demonstrated in an anti-Ia serum the presence of specific antibodies reacting with T cells, as well as with B cells, using a highly sensitive dye exclusion test. This antiserum reacts with both spleen and lymph node in a characteristic biphasic titration curve killing up to 70% of these cells. It also reacts with cortisone-resistant thymocytes. The A.TH-alpha-A.TL serum can be absorbed with spleen, lymph node, cortisone-resistant thymus, or normal thymus cells. Further in vivo absorptions in BALB/c nude cannot remove all of the cytotoxic activity for normal BALB lymph node lymphocytes, while completely removing the activity for nude cells. A Thy-1 positive cell line derived from a C57Br leukemia is reactive with this anti-Ia serum.
摘要
我们使用高度敏感的染料排除试验，在一种抗Ia血清中证实了存在与T细胞以及B细胞发生反应的特异性抗体。这种抗血清与脾脏和淋巴结反应，呈现出特征性的双相滴定曲线，可杀死高达70%的这些细胞。它也与皮质激素抗性胸腺细胞反应。A.TH-α-A.TL血清可被脾脏、淋巴结、皮质激素抗性胸腺或正常胸腺细胞吸收。在BALB/c裸鼠体内进一步吸收，不能消除对正常BALB淋巴结淋巴细胞的所有细胞毒性活性，而能完全消除对裸鼠细胞的活性。源自C57Br白血病的Thy-1阳性细胞系与这种抗Ia血清反应。
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