Department of Neurological Surgery, Mayo Clinic, Jacksonville, FL, USA.
NeurosurgeryOne, Littleton, CO, USA.
Neurosurg Clin N Am. 2021 Jan;32(1):1-8. doi: 10.1016/j.nec.2020.09.005. Epub 2020 Nov 5.
The clinical presentation of glioblastomas is varied, and definitive diagnosis requires pathologic examination and study of the tissue. Management of glioblastomas includes surgery and adjuvant chemotherapy and radiotherapy, with surgery playing an important role in the prognosis of these patients. Awake craniotomy plays a crucial role in tumors in or adjacent to eloquent areas, allowing surgeons to maximize resection, while minimizing iatrogenic deficits. However, the prognosis remains dismal. This article presents the perioperative management of patients with glioblastoma including tools and surgical adjuncts to maximize extent of resection and minimize poor outcomes.
胶质母细胞瘤的临床表现多种多样，明确的诊断需要病理检查和组织研究。胶质母细胞瘤的治疗包括手术和辅助化疗及放疗，手术在这些患者的预后中起着重要作用。在功能区或邻近功能区的肿瘤中，唤醒开颅术起着至关重要的作用，它使外科医生能够最大限度地切除肿瘤，同时最大限度地减少医源性缺陷。然而，预后仍然很差。本文介绍了胶质母细胞瘤患者的围手术期管理，包括最大限度地切除肿瘤和减少不良预后的工具和手术辅助手段。
