Medical University of Gdansk, Gdańsk, Poland (Department of Clinical Toxicology).
Int J Occup Med Environ Health. 2021 Jan 7;34(1):133-138. doi: 10.13075/ijomeh.1896.01629. Epub 2020 Nov 13.
Morphine is an opiate alkaloid characterized by various clinical effects, among which the most prominent are its analgesic and psychoactive effects. It also has a prominent depressive effect on the respiratory and cardiovascular system. Because of its psychoactive effect, morphine is very addictive and often used as a recreational narcotic. As a medication, it has found its use as an analgesic agent in chronic pain treatment, in hemorrhagic shock, and in acute heart failure with pulmonary edema. Albeit, morphine use in heart failure is controversial, based on many observational studies showing the negative effect on the outcomes of the patients treated with morphine during acute cardiovascular incidents. In this report, the authors present a case of cardiogenic shock (CS) with transient left ventricular ejection fraction reduction, occurring in a patient attempting suicide using a high dose of intravenous morphine sulphate administration. Other CS causes were ruled out. To the best of the authors' knowledge, this is the second case of a morphine-related CS reported in literature. Int J Occup Med Environ Health. 2021;34(1):133-8.
吗啡是一种阿片生物碱，具有多种临床作用，其中最突出的是其镇痛和精神活性作用。它还对呼吸和心血管系统有明显的抑制作用。由于其精神活性作用，吗啡非常容易上瘾，常被用作消遣性麻醉剂。作为一种药物，它已被用于慢性疼痛治疗、失血性休克和急性心力衰竭伴肺水肿的镇痛剂。尽管如此，基于许多观察性研究表明在急性心血管事件期间使用吗啡治疗的患者的结局呈负面影响，吗啡在心力衰竭中的应用仍存在争议。在本报告中，作者报告了一例使用高剂量静脉注射硫酸吗啡后发生的心原性休克（CS）伴短暂左心室射血分数降低的病例。排除了其他 CS 病因。据作者所知，这是文献中报告的第二例与吗啡相关的 CS 病例。国际职业医学与环境卫生杂志。2021;34(1):133-8.
