Rustin M H, Almond N E, Beacham J A, Brooks R J, Jones D P, Cooke E D, Dowd P M
Department of Dermatology, Middlesex Hospital, London, U.K.
Br J Dermatol. 1987 Dec;117(6):751-8. doi: 10.1111/j.1365-2133.1987.tb07356.x.
Fifteen patients with primary Raynaud's phenomenon received captopril 25 mg or placebo, three times daily for 6 weeks, in a randomized double-blind cross-over study. Compared with placebo, captopril produced a significant improvement in cutaneous blood flow but did not alter the frequency or severity of attacks of Raynaud's phenomenon.
在一项随机双盲交叉研究中,15名原发性雷诺现象患者接受了卡托普利25毫克或安慰剂治疗,每日三次,持续6周。与安慰剂相比,卡托普利使皮肤血流量有显著改善,但并未改变雷诺现象发作的频率或严重程度。