两种双胍类化合物——0.2%聚己缩胍和2%氯己定在人牙本质上的附着性比较评估
Comparative evaluation of substantivity of two biguanides - 0.2% polyhexanide and 2% chlorhexidine on human dentin.
作者信息
Chandki Rita, Nikhil Vineeta, Kalyan S Sai
机构信息
Swami Vivekanand Subharti University, Meerut, Uttarpradesh, India.
Department of Conservative Dentistry and Endodontics, Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India.
出版信息
J Conserv Dent. 2020 Jan-Feb;23(1):46-50. doi: 10.4103/JCD.JCD_256_19. Epub 2020 Oct 10.
BACKGROUND
Substantivity is one of the desirable characteristics of root canal irrigants. Among conventional endodontic irrigants, only chlorhexidine (CHX) is known to exert significant substantivity on root canal dentin. This study explored the substantivity activity of a polymeric biguanide-poly hexamethylene biguanide (PHMB).
AIM
The aim of this study was to determine the substantivity of a polymeric biguanide - 0.2% PHMB and compare it with that of 2% CHX.
MATERIALS AND METHODS
To evaluate and compare the substantivity of 0.2% PHMB and 2% CHX on root canal dentin, dentin disks were prepared and substantivity after 1 h, 24 h, 7 days and 21 days was measured using spectrophotometry.
STATISTICAL ANALYSIS USED
The data so obtained were analyzed, and the intergroup comparison was made using unpaired -test.
RESULTS
The results of this study indicated that 0.2%. PHMB exerts significantly greater substantivity than 2% CHX on human dentin.
CONCLUSION
Within the limitations, this study supports the use of 0.2% polyhexanide as an endodontic irrigant based on its property of substantivity.
背景
持续性是根管冲洗剂的理想特性之一。在传统的牙髓病冲洗剂中，已知只有洗必泰（CHX）能对根管牙本质产生显著的持续性。本研究探讨了一种聚合双胍——聚六亚甲基双胍（PHMB）的持续性活性。
目的
本研究的目的是测定一种聚合双胍——0.2% PHMB的持续性，并将其与2% CHX的持续性进行比较。
材料与方法
为了评估和比较0.2% PHMB和2% CHX对根管牙本质的持续性，制备了牙本质盘，并使用分光光度法测量了1小时、24小时、7天和21天后的持续性。
所用统计分析
对所获得的数据进行分析，并使用非配对t检验进行组间比较。
结果
本研究结果表明，0.2% PHMB对人牙本质的持续性显著高于2% CHX。
结论
在本研究的局限性范围内，基于其持续性特性，本研究支持使用0.2%聚己双胍作为牙髓病冲洗剂。
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