Unique behavioral effects of the NMDA antagonist, CPP, upon injection into the medial pre-frontal cortex of rats.
作者信息
O'Neill K A, Liebman J M
机构信息
Pharmaceuticals Division, Ciba-Geigy Corporation, Summit, NJ 07901.
出版信息
Brain Res. 1987 Dec 1;435(1-2):371-6. doi: 10.1016/0006-8993(87)91628-3.
PMID:3322505
Abstract
Injection of the specific N-methyl-D-aspartate (NMDA) antagonist, 3(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), into the frontal cortex of rats, induced hyperactivity characterized by unique episodic darting behavior. This behavioral profile contrasts sharply with the ataxia and hyperactivity seen after intracerebroventricular CPP and other NMDA antagonists.
摘要
Zotero 插件