Yadegarfar Ghasem, Anderson Simon G, Khawaja Zohaib, Cortes Gabriela, Leivesley Kathryn, Metters Ann, Horne Linda, Steele Tom, Heald Adrian H
The School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, UK.
Heart Failure Research Center, Cardiovascular Research Institute, & School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Cardiovasc Endocrinol Metab. 2020 Jun 16;9(4):171-176. doi: 10.1097/XCE.0000000000000216. eCollection 2020 Dec.
Many people with type 1 diabetes continue to run high HbA1c levels with associated elevated risk of cardiovascular events and increased mortality. We describe here how use of the FreeStyle Libre flash monitor has improved the glycaemic control of many people with type 1 diabetes where the new technology has been intensively deployed.
We report the outcomes of 92 consecutive adults (18 years of age or more) with type 1 diabetes who have begun using the FreeStyle Libre flash glucose monitor in East Cheshire, UK. Initiation was with education and support from one of the diabetes specialist nurses. An HbA1c of 60 mmol/mol (7.6%) was taken as the threshold for suboptimal glycaemic control.
The mean cohort age was 43 years for men and 39 years for women (overall range 17-83 years). In 92 consecutive users, HbA1c decreased by an average of 10.7 mmol/mol (0.98%) after 3 months, and by 16.1 mmol/mol (1.47%) after 6 months. There was also a narrowing of the distribution of HbA1c, with many fewer people running high HbA1c ≥80 mmol/mol (9.5%). After the 6-month follow-up, two 2/92 users did not wish to continue with the monitoring.
Flash glucose monitoring has great potential for the management of type 1 diabetes in the adult population and improving metabolic control/quality of life for people across the world. The technology provides significantly more data than the intermittent results obtained by traditional subcutaneous blood glucose monitoring, which may not capture intervals of extreme variability or nocturnal events.
许多1型糖尿病患者的糖化血红蛋白（HbA1c）水平持续居高不下，心血管事件风险相应升高，死亡率也有所增加。在此，我们描述了在新技术得到密集应用的情况下，使用FreeStyle Libre闪测仪如何改善了许多1型糖尿病患者的血糖控制。
我们报告了英国柴郡东部92名连续入组的18岁及以上成年1型糖尿病患者开始使用FreeStyle Libre闪测仪的结果。在一名糖尿病专科护士的教育和支持下开始使用。将糖化血红蛋白60 mmol/mol（7.6%）作为血糖控制不佳的阈值。
队列中男性的平均年龄为43岁，女性为39岁（总体年龄范围为17 - 83岁）。在92名连续使用者中，3个月后糖化血红蛋白平均下降10.7 mmol/mol（0.98%），6个月后下降16.1 mmol/mol（1.47%）。糖化血红蛋白的分布也变窄了，糖化血红蛋白≥80 mmol/mol（9.5%）的高值人群减少。6个月随访后，92名使用者中有2人不希望继续监测。
闪测血糖对成人1型糖尿病的管理以及改善全球患者的代谢控制/生活质量具有巨大潜力。该技术提供的数据比传统皮下血糖监测获得的间歇性结果多得多，传统监测可能无法捕捉到极端变异性的时间段或夜间事件。
