Tanaka Shin, Luis Campo-Cañaveral de la Cruz Jose, Crowley Carrasco Silvana, Romero Román Alejandra, Hoyos Mejía Lucas, Manuel NaranjoGómez Jose, Córdoba Peláez Mar, Sánchez Calle Álvaro, Gil Barturen Mariana, Pérez Redondo Marina, García Fadul Christian, Varela de Ugarte Andrés, Gómez-de-Antonio David
Department of Thoracic Surgery and Lung Transplantation, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
Intensive Care Unit, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
Eur J Cardiothorac Surg. 2020 Nov 23. doi: 10.1093/ejcts/ezaa398.
Controlled donation after circulatory death (cDCD) donors are becoming a common source of organs for transplantation globally. However, the graft survival rate of cDCD abdominal organs is inferior to that of organs from brain-dead donors. The rapid retrieval (RR) technique is used by most donor organ procurement teams. The abdominal normothermic regional perfusion (A-NRP) technique has been implemented to minimize warm ischaemic damage to the abdominal organs. However, there is limited information on the effect of A-NRP on the quality of the donor lungs. This study aimed to compare lung transplantation outcomes using lungs procured from cDCD donors using the A-NRP and abdominal RR techniques.
A single-centre retrospective analysis of consecutive transplant recipients of cDCD lungs from June 2013 to December 2019 was performed. The recipients were divided into 2 cohorts according to the abdominal procurement technique used. The recipient and donor characteristics (age, sex, cause of brain injury, warm ischaemic time, diagnosis, lung allocation score and other factors), incidence of primary graft dysfunction and early survival were monitored.
Twenty-eight consecutive lung transplantation recipients were identified (median age 59 years; 61% male); 14 recipients received lungs using the A-NRP and 14 using abdominal RR for abdominal organ retrieval. There were no significant differences in the baseline characteristics, primary graft dysfunction (P = 0.70), hospital mortality (P = 1.0) and 1-year survival rate (P = 1.0) between the 2 groups.
No difference was observed in lung transplantation outcomes irrespective of the abdominal organ procurement technique used (A-NRP or abdominal RR).
