Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Santa Catarina, Brazil.
J Psychoactive Drugs. 2021 Apr-Jun;53(2):168-176. doi: 10.1080/02791072.2020.1849878. Epub 2020 Nov 22.
Using psychiatric drugs to treat drug dependence and its comorbidities is very common. The objective of this study was to analyze the interactions between prescribed drugs for patients treated at a specialized mental health-care center for persons who use drugs, located in the state of Santa Catarina, Brazil. A cross-sectional study was conducted on secondary data collected from 2010 to 2018. We reviewed the medical records of patients aged 18 years or older who took psychotropic drugs and had any type of substance dependence. The analysis of psychotropic drug interactions was conducted in three databases: , and . We included 1,022 of the 2,322 patients attending the care center during the study period. Psychotropic drug interactions were found in 779 (76.4%) study participants, and they presented 2,292 (100%) interactions, out of which 136 (6.0%) had minor clinical risk, 537 (23.4%) had moderate risk, and 1,619 (70.6%) had major risk for the patient, totaling 172 incompatible combinations between two psychotropic drugs. Of the total number of interactions, 128 were pharmacokinetic and 44 were pharmacodynamic. The high number of psychotropic drug interactions is a serious public health issue. Psychopharmacological treatment should be carefully addressed to be safe for the patient.
使用精神科药物治疗药物依赖及其共病是非常常见的。本研究的目的是分析巴西圣卡塔琳娜州一家专门为吸毒者提供精神保健的中心治疗的患者所开处方药物之间的相互作用。这是一项回顾性的队列研究，研究数据来源于 2010 年至 2018 年期间收集的二级资料。研究对象为在该中心接受治疗且年龄在 18 岁及以上、使用精神药物且有任何类型物质依赖的患者。我们在三个数据库中对精神药物相互作用进行了分析：、和。在研究期间，共有 2322 名患者到该护理中心就诊，其中有 1022 名患者符合纳入标准。在 779 名（76.4%）研究参与者中发现了精神药物相互作用，共有 2292 项（100%）相互作用，其中 136 项（6.0%）有轻微的临床风险，537 项（23.4%）有中度风险，1619 项（70.6%）有较大风险，共计有 172 项两种精神药物之间的不相容组合。在所有相互作用中，有 128 项为药代动力学相互作用，44 项为药效学相互作用。精神科药物相互作用的数量较多是一个严重的公共卫生问题。精神药物治疗应该谨慎进行，以确保患者的安全。
