El Hoffy Nada M, Abdel Azim Engy A, Hathout Rania M, Fouly Marwa A, Elkheshen Seham A
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt.
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Eur J Pharm Sci. 2021 Mar 1;158:105648. doi: 10.1016/j.ejps.2020.105648. Epub 2020 Nov 21.
Glaucoma, being asymptomatic for relatively late stage, is recognized as a worldwide cause of irreversible vision loss. The eye is an impervious organ that exhibits natural anatomical and physiological barriers which renders the design of an efficient ocular delivery system a formidable task and challenge scientists to find alternative formulation approaches. In the field of glaucoma treatment, smart delivery systems for targeting have aroused interest in the topical ocular delivery field owing to its potentiality to oppress many treatment challenges associated with many of glaucoma types. The current momentum of nano-pharmaceuticals, in the development of advanced drug delivery systems, hold promises for much improved therapies for glaucoma to reduce its impact on vision loss. In this review, a brief about glaucoma; its etiology, predisposing factors and different treatment modalities has been reviewed. The diverse ocular drug delivery systems currently available or under investigations have been presented. Additionally, future foreseeing of new drug delivery systems that may represent potential means for more efficient glaucoma management are overviewed. Finally, a gab-analysis for the required investigation to pave the road for commercialization of ocular novel-delivery systems based on the nano-technology are discussed.
青光眼在相对晚期时无症状，是全球不可逆视力丧失的一个原因。眼睛是一个封闭的器官，具有天然的解剖和生理屏障，这使得设计高效的眼部给药系统成为一项艰巨的任务，并促使科学家寻找替代的制剂方法。在青光眼治疗领域，用于靶向的智能给药系统因其有潜力克服与多种青光眼类型相关的许多治疗挑战而引起了局部眼部给药领域的关注。纳米药物在先进药物递送系统开发中的当前发展态势，有望为青光眼带来显著改善的治疗方法，以减少其对视力丧失的影响。在这篇综述中，简要介绍了青光眼；其病因、诱发因素和不同的治疗方式。介绍了目前可用或正在研究的各种眼部给药系统。此外，概述了可能代表更有效青光眼管理潜在手段的新型药物递送系统的未来展望。最后，讨论了为基于纳米技术的眼部新型递送系统商业化铺平道路所需研究的综合分析。
