Implications of the neglect of stereochemistry in pharmacokinetics and clinical pharmacology.
作者信息
Ariëns E J
机构信息
Institute of Pharmacology and Toxicology, University of Nijmegen, The Netherlands.
出版信息
Drug Intell Clin Pharm. 1987 Oct;21(10):827-9. doi: 10.1177/106002808702101013.
PMID:3322758
Abstract
An outline is given of the implications of stereoselectivity in biological action and the use of racemic fixed-ratio combinations in pharmacology and pharmacotherapeutics. Pitfalls of the neglect of stereochemistry, such as generation of senseless pharmacokinetic data, are exemplified and emphasized.
摘要
Zotero 插件