Implications of the neglect of stereochemistry in pharmacokinetics and clinical pharmacology.
作者信息
Ariëns E J
机构信息
Institute of Pharmacology and Toxicology, University of Nijmegen, The Netherlands.
出版信息
Drug Intell Clin Pharm. 1987 Oct;21(10):827-9. doi: 10.1177/106002808702101013.
PMID:3322758
Abstract
An outline is given of the implications of stereoselectivity in biological action and the use of racemic fixed-ratio combinations in pharmacology and pharmacotherapeutics. Pitfalls of the neglect of stereochemistry, such as generation of senseless pharmacokinetic data, are exemplified and emphasized.
摘要
相似文献
1
Implications of the neglect of stereochemistry in pharmacokinetics and clinical pharmacology.
Drug Intell Clin Pharm. 1987 Oct;21(10):827-9. doi: 10.1177/106002808702101013.
2
Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology.立体化学，药代动力学和临床药理学中复杂无稽之谈的一个基础。
Eur J Clin Pharmacol. 1984;26(6):663-8. doi: 10.1007/BF00541922.
3
The importance of stereochemistry in drug action and disposition.
J Clin Pharmacol. 1992 Oct;32(10):925-9. doi: 10.1002/j.1552-4604.1992.tb04640.x.
4
[Stereochemistry and drug effects--a neglected field of knowledge].
Lakartidningen. 2006;103(17):1305-6, 1309-11.
5
Stereochemistry and bioequivalence.立体化学与生物等效性
J Clin Pharmacol. 1992 Oct;32(10):930-4. doi: 10.1002/j.1552-4604.1992.tb04641.x.
6
[Drug chirality].
Ceska Slov Farm. 2002 Jan;51(1):17-25.
7
Stereoselectivity and affinity in molecular pharmacology.
Prog Drug Res. 1976;20:101-42. doi: 10.1007/978-3-0348-7094-8_4.
8
Stereoselectivity of bioactive xenobiotics. A pre-Pasteur attitude in medicinal chemistry, pharmacokinetics and clinical pharmacology.生物活性外源性物质的立体选择性。药物化学、药代动力学和临床药理学中的一种前巴斯德态度。
Biochem Pharmacol. 1988 Jan 1;37(1):9-18. doi: 10.1016/0006-2952(88)90749-6.
9
Pharmacokinetic and pharmacodynamic consequences of stereoselective drug metabolism in man.人体中立体选择性药物代谢的药代动力学和药效学后果
Biochem Pharmacol. 1988 Jan 1;37(1):93-6. doi: 10.1016/0006-2952(88)90758-7.
10
Chirality: pharmacokinetics and pharmacodynamics in 3 dimensions.
Clin Exp Pharmacol Physiol. 1989 Jun;16(6):465-70. doi: 10.1111/j.1440-1681.1989.tb01589.x.
引用本文的文献
1
Pharmacological importance of stereochemical resolution of enantiomeric drugs.对映体药物立体化学拆分的药理学重要性。
Drug Saf. 1997 Sep;17(3):149-65. doi: 10.2165/00002018-199717030-00002.
2
Stereoselectivity, a natural aspect of molecular biology: a blind spot in clinical pharmacology and pharmacokinetics.
Eur J Drug Metab Pharmacokinet. 1988 Oct-Dec;13(4):307-8. doi: 10.1007/BF03190095.
3
Clinical pharmacokinetics 1990.
Clin Pharmacokinet. 1990 Jan;18(1):1-19. doi: 10.2165/00003088-199018010-00001.
Zotero 插件