用阿那白滞素成功治疗儿童暴发性脑病伴难治性癫痫综合征（FIRES） - Suppr

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超能文献

Successful Treatment of Pediatric FIRES With Anakinra.

作者信息

Yang Jennifer H, Nataraj Shilpa, Sattar Shifteh

机构信息

Division of Child Neurology, University of California San Diego and Rady Children's Hospital, San Diego, California.

University of California San Diego School of Medicine, San Diego, California.

出版信息

Pediatr Neurol. 2021 Jan;114:60-61. doi: 10.1016/j.pediatrneurol.2020.10.009. Epub 2020 Oct 22.

DOI:10.1016/j.pediatrneurol.2020.10.009

PMID:33227629

Abstract

摘要

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Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions.新起难治性癫痫持续状态（NORSE）、感染相关性癫痫综合征（FIRES）及相关情况的共识定义建议。

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New-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES): State of the art and perspectives.新起难治性癫痫持续状态（NORSE）和热性感染相关癫痫综合征（FIRES）：现状与展望。

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The Beneficial Outcome of Subsequent Treatment with Anakinra during the Chronic Phase of Febrile Infection-Related Epilepsy Syndrome (FIRES): A Case Report.在发热感染相关癫痫综合征（FIRES）慢性期使用阿那白滞素进行后续治疗的有益结果：一例报告

Neurol Int. 2023 Dec 11;15(4):1489-1496. doi: 10.3390/neurolint15040097.

A practical approach to in-hospital management of new-onset refractory status epilepticus/febrile infection related epilepsy syndrome.医院内新发难治性癫痫持续状态/发热感染相关癫痫综合征的实用管理方法。

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Systemic inflammation as a biomarker of seizure propensity and a target for treatment to reduce seizure propensity.全身性炎症作为癫痫倾向的生物标志物和治疗靶点以降低癫痫倾向。

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Towards a Treatment for Neuroinflammation in Epilepsy: Interleukin-1 Receptor Antagonist, Anakinra, as a Potential Treatment in Intractable Epilepsy.针对癫痫的神经炎症治疗：白细胞介素-1 受体拮抗剂阿那白滞素作为难治性癫痫的潜在治疗方法。

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Hypothesis: Febrile infection-related epilepsy syndrome is a microglial NLRP3 inflammasome/IL-1 axis-driven autoinflammatory syndrome.假说：发热感染相关癫痫综合征是一种由小胶质细胞NLRP3炎性小体/白细胞介素-1轴驱动的自身炎症综合征。

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