Dentistry and Maxillofacial Surgery Section, Department of Surgery, Dentistry, Pediatrics and Gynecology (DIPSCOMI), University of Verona, Verona, Italy.
Microbiology Section, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Undersea Hyperb Med. 2020 Fourth Quarter;47(4):571-580. doi: 10.22462/10.12.2020.6.
To clinically and microbiologically evaluate the effects of hyperbaric oxygen (HBO2) therapy in addition to full-mouth ultrasonic subgingival debridement (FM-UD), in the initial treatment of chronic periodontitis.
Twenty patients presenting moderate to severe generalized forms of chronic periodontitis were included in a three-month randomized, parallel-group, single-blinded, prospective study. At baseline patients were randomly assigned to two treatment groups [Test Group (FM-UD+HBO2) and Control Group (FM-UD)]. Both groups were treated with an FM-UD session. Ten HBO2 sessions (one session per day for 10 days at a pressure of 2.5 ATA) were additionally administered to the Test Group. Soft tissues parameters [probing pocket depth (PPD), bleeding on probing (BOP), clinical attachment level (CAL) and visible plaque index (VPI)] were assessed at baseline (immediately before FM-UD treatment), after two weeks, after six weeks and at three months. For each patient, a site presenting PPD ≥ 6mm and positive BOP was selected as a qualifying site (QS), to be monitored clinically (at T0, T1, T2 and T3) and microbiologically (at T0, T1 and T3).
There were no statistically significant differences between the two groups for any clinical parameter analyzed after three months, except for BOP, which was significantly (p < 0.05) reduced in the Test Group. Reductions in bacterial levels were detected in both groups after therapy. Faster bacterial recolonization occurred after three months in the Control Group.
HBO2 therapy in combination with FM-UD may represent an efficacious approach to the treatment of moderate to severe forms of periodontitis.
评估高压氧（HBO2）治疗联合全口超声龈下刮治（FM-UD）对慢性牙周炎初始治疗的临床和微生物学效果。
将 20 名患有中重度慢性牙周炎的患者纳入一项为期三个月的随机、平行组、单盲、前瞻性研究。在基线时，患者被随机分配到两个治疗组[试验组（FM-UD+HBO2）和对照组（FM-UD）]。两组均接受 FM-UD 治疗。试验组额外接受 10 次 HBO2 治疗（每天一次，压力为 2.5ATA，持续 10 天）。在基线（FM-UD 治疗前）、两周后、六周后和三个月后评估软组织参数[探诊深度（PPD）、探诊出血（BOP）、临床附着水平（CAL）和可见菌斑指数（VPI）]。对于每个患者，选择一个 PPD≥6mm 和 BOP 阳性的部位作为合格部位（QS），进行临床（T0、T1、T2 和 T3）和微生物监测（T0、T1 和 T3）。
三个月后，除 BOP 外，两组在任何临床参数上均无统计学差异，而 BOP 在试验组中显著降低（p<0.05）。治疗后两组细菌水平均降低。对照组在三个月后出现更快的细菌再定植。
HBO2 治疗联合 FM-UD 可能是治疗中重度牙周炎的有效方法。
