Lôo H, Hantzberg P, Defrance R, Kamoun A, Deniker P
Service hospitalo-universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte-Anne, Paris.
Encephale. 1987 Sep-Oct;13(5):295-9.
The study concerns the use of a new antidepressant, tianeptine, as a treatment of depressive and/or amotival syndrome, in 30 drug addicts, detoxified from opiates. From a thymoanaleptic point of view, 85% of the patients exhibit a positive result after 28 days of treatment with 37.5 mg/day. These good results are confirmed by the evolution of the Hamilton Depression Rating Scale global score, which significantly decreases from D0 to D14 and from D14 to D28. The acceptability of the antidepressant is good. Anticholinergic side-effects are very uncommon. Tianeptine appears devoid of any obvious psychostimulant or sedative effect. The drug compliance, estimated by counting the tablets, is very satisfying: there is no tendency to a spontaneous increase of dosing. The follow-up of the patients after drug cessation has not shown any symptoms suggesting psychological or physical dependence towards the drug. During this study in subjects particularly predisposed to the abuse of psychoactive drugs, tianeptine has not induced anything suggesting the possibility of drug abuse or tolerance.
该研究关注新型抗抑郁药噻奈普汀用于治疗30名已戒除阿片类药物的吸毒者的抑郁和/或无动机综合征的情况。从抗抑郁的角度来看，85%的患者在接受37.5毫克/天的治疗28天后呈现阳性结果。汉密尔顿抑郁评定量表总分的变化证实了这些良好结果，该总分从第0天到第14天以及从第14天到第28天显著下降。这种抗抑郁药的可接受性良好。抗胆碱能副作用非常罕见。噻奈普汀似乎没有任何明显的精神兴奋或镇静作用。通过计算药片数量评估的药物依从性非常令人满意：没有自发增加剂量的趋势。停药后对患者的随访未显示出任何表明对该药物存在心理或生理依赖的症状。在这项针对特别容易滥用精神活性药物的受试者的研究中，噻奈普汀未引发任何表明存在药物滥用或耐受性可能性的情况。
