Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA; email:
Annu Rev Med. 2021 Jan 27;72:183-197. doi: 10.1146/annurev-med-052819-023848. Epub 2020 Nov 23.
Eosinophilic esophagitis (EoE) is a relatively recently identified but now frequently encountered antigen/immune-mediated disease which places significant burden on patients and the healthcare system. With its growing prevalence and recognition by healthcare providers in multiple disciplines, substantial progress has been made regarding the diagnostic criteria, clinical evaluation, tools for disease assessment, and immune pathways related to pathogenesis. Current treatment goals focus on the amelioration of inflammation and prevention of remodeling consequences using proton pump inhibitors, swallowed topical steroids, elimination diets, and esophageal dilation. Ongoing research holds promise for more efficacious and targeted therapies as well as a personalized approach to the care of patients with EoE.
嗜酸性食管炎（EoE）是一种相对较新发现但现在经常遇到的抗原/免疫介导的疾病，给患者和医疗保健系统带来了巨大负担。随着其患病率的增加和多个学科的医疗保健提供者的认识，在诊断标准、临床评估、疾病评估工具以及与发病机制相关的免疫途径方面取得了重大进展。目前的治疗目标集中在使用质子泵抑制剂、口服局部类固醇、消除饮食和食管扩张来减轻炎症和预防重塑后果。正在进行的研究有望为更有效和有针对性的治疗以及为 EoE 患者的护理提供个性化方法提供希望。
