Lopez-Vidriero M T
Department of Thoracic Medicine, Royal Free Hospital School of Medicine, London, UK.
Eur J Respir Dis Suppl. 1987;153:130-5.
The physical properties of respiratory tract secretion (RTS) play a prominent rôle in the non-specific defence mechanisms of the lung. Viscosity and elasticity, that is flow and deformation, are only two of the physical properties of RTS. Spinability, pourability, adhesiveness and tackiness are starting to be recognised as physical properties of RTS and its is likely that they may be relevant in the pathogenesis of airways obstruction. RTS is a gel, which consists of a cross-linked polymer network dispersed in a liquid solvent. The polymeric structure of the epithelial glycoprotein can be explained in terms of covalent (disulphide) linkages and/or physical entanglement between glycoproteins subunits. Other constituents of RTS such as proteins, lipids, ions and water can influence the physical properties of RTS.
呼吸道分泌物（RTS）的物理特性在肺部的非特异性防御机制中起着重要作用。粘度和弹性，即流动性和变形性，只是RTS的两个物理特性。可纺性、可倾倒性、粘附性和粘性开始被认为是RTS的物理特性，并且它们可能与气道阻塞的发病机制有关。RTS是一种凝胶，由分散在液体溶剂中的交联聚合物网络组成。上皮糖蛋白的聚合物结构可以用糖蛋白亚基之间的共价（二硫键）连接和/或物理缠结来解释。RTS的其他成分，如蛋白质、脂质、离子和水，会影响RTS的物理特性。
