Heralgi Mallikarjun M, Kavitha V, Dwivedi Manisha, Preethi V, Roopasree B V, Rajashekar J, Deokar Ankit
Cornea and Refractive Surgery Department, Sankara Eye Hospital, Shimoga, Karnataka, India.
Department of Pediatric Ophthalmology, Sankara Eye Hospital, Shimoga, Karnataka, India.
Indian J Ophthalmol. 2020 Dec;68(12):2975-2980. doi: 10.4103/ijo.IJO_1399_20.
The aim of this work was to study the change in contrast sensitivity (CS) in relation to depth of stromal ablation after wavefront-optimized (WFO) myopic laser in situ keratomileusis (LASIK).
This was as prospective, longitudinal, comparative study. The study participants were divided into two groups: Group 1 ≤50 μ ablation depth; 60 eyes and group 2 >50 μ ablation depth; 60 eyes. All underwent WFO LASIK. Uncorrected and corrected distance visual acuity (UDVA and CDVA) and CS were measured preoperatively and postoperatively at 1 week, 2 weeks, and 2 and 6 months. Two-way repeated-measures analysis of variance (ANOVA), Unpaired t test and one-way repeated measures ANOVA were used to test differences across time periods within each treatment group. A value of P < 0.05 was considered as statistically significant.
The mean ablation depths in groups 1 and 2 were 39.30 μ ± 7.22 μ and 69.90 μ ± 12.09 μ, respectively; the maximum depth was 94.62 μ. In group 1, the preoperative mean CS was 1.91 ± 0.07, which improved postoperatively at 1 week (1.93 ± 0.06) and remained stable in subsequent follow-ups (1.94 ± 0.05). In group 2, the mean CS preoperatively was 1.87 ± 0.12, which postoperatively at 1 week and 6 months were 1.93 ± 0.07 and 1.94 ± 0.03, respectively (P < 0.05). Between the groups, preoperative CS was significantly different (P = 0.04), but the change in CS post-LASIK was insignificant (P > 0.05).
There was a significant improvement in CS after WFO myopic LASIK in all patients irrespective of ablation depth (up to 94.62 μ).
本研究旨在探讨波前优化（WFO）的准分子激光原位角膜磨镶术（LASIK）后，对比敏感度（CS）随基质消融深度的变化情况。
这是一项前瞻性、纵向、对比研究。研究对象分为两组：第1组消融深度≤50μm，共60眼；第2组消融深度>50μm，共60眼。所有患者均接受WFO LASIK手术。术前及术后1周、2周、2个月和6个月测量未矫正及矫正远视力（UDVA和CDVA）和CS。采用双向重复测量方差分析（ANOVA）、非配对t检验和单向重复测量ANOVA检验各治疗组不同时间段的差异。P<0.05被认为具有统计学意义。
第1组和第2组的平均消融深度分别为39.30μm±7.22μm和69.90μm±12.09μm；最大深度为94.62μm。第1组术前平均CS为1.91±0.07，术后1周改善（1.93±0.06），随后随访中保持稳定（1.94±0.05）。第2组术前平均CS为1.87±0.12，术后1周和6个月分别为1.93±0.07和1.94±0.03（P<0.05）。两组间术前CS有显著差异（P=0.04），但LASIK术后CS的变化无显著差异（P>0.05）。
无论消融深度如何（最深达94.62μm），所有患者在接受WFO近视LASIK术后CS均有显著改善。
