Department of Nephrology, Health Science University Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Department of Nephrology, Uludag University Faculty of Medicine, Bursa, Turkey.
Saudi J Kidney Dis Transpl. 2020 Sep-Oct;31(5):1014-1024. doi: 10.4103/1319-2442.301166.
Spondin 2 (SPON2) plays an important role in multiple processes and is a member of the Spondin 2/F-spondin family of extracellular matrix proteins. We investigated serum SPON2 levels and its correlation with renal functions and urine protein excretion in different glomerular diseases. The cohort included 97 consecutive adults with persistant proteinuria (>300 mg/day) with the diagnosis of focal segmental glomerulosclerosis (FSGS), membranous glomerulonephritis (MN), IgA nephropathy (IgAN), membranoproliferative glomerulonephritis (MPGN), and AA amyloidosis and the control groups with 15 polycystic kidney disease (PKD) and 32 healthy people. Serum SPON2 levels in MN (64.6 ng/mL), FSGS (47.8 ng/mL), IgAN (52.6 ng/mL), MPGN (54.6 ng/mL), and AA amyloidosis (60.7 ng/mL) groups were higher than those of the control (26.4 ng/mL) and nonglomerular disease groups (PKD) (15.3 ng/mL). Only serum SPON2 levels were correlated with serum uric acid and triglyceride levels in patients with glomerular disease. This is the first study to show that serum SPON2 levels are similar in different glomerular diseases and that there is no correlation between SPON2 and proteinuria grade.
Spondin 2（SPON2）在多种过程中发挥重要作用，是细胞外基质蛋白 Spondin 2/F-spondin 家族的成员。我们研究了不同肾小球疾病患者血清 SPON2 水平及其与肾功能和尿蛋白排泄的相关性。该队列包括 97 例连续的持续性蛋白尿（>300mg/天）成人，诊断为局灶节段性肾小球硬化症（FSGS）、膜性肾小球肾炎（MN）、IgA 肾病（IgAN）、膜增殖性肾小球肾炎（MPGN）和 AA 淀粉样变性，对照组包括 15 例多囊肾病（PKD）和 32 例健康人。MN（64.6ng/mL）、FSGS（47.8ng/mL）、IgAN（52.6ng/mL）、MPGN（54.6ng/mL）和 AA 淀粉样变性（60.7ng/mL）组的血清 SPON2 水平高于对照组（26.4ng/mL）和非肾小球疾病组（PKD）（15.3ng/mL）。只有肾小球疾病患者的血清 SPON2 水平与血清尿酸和甘油三酯水平相关。这是第一项表明不同肾小球疾病患者血清 SPON2 水平相似且 SPON2 与蛋白尿分级无相关性的研究。
