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New Evidence of Probucol on Cardiovascular Events.

作者信息

Hirata Ken-Ichi

机构信息

The Cardiovascular Medicine, Kobe University Graduate School of Medicine.

出版信息

J Atheroscler Thromb. 2021 Feb 1;28(2):97-99. doi: 10.5551/jat.ED155. Epub 2020 Nov 21.

DOI:10.5551/jat.ED155
PMID:33229816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7957033/
Abstract
摘要

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New Evidence of Probucol on Cardiovascular Events.普罗布考对心血管事件影响的新证据
J Atheroscler Thromb. 2021 Feb 1;28(2):97-99. doi: 10.5551/jat.ED155. Epub 2020 Nov 21.
2
New Horizons for Probucol, an Old, Mysterious Drug.普罗布考，一种古老而神秘药物的新前景。
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3
[Mechanisms of anti-atherogenic action of probucol].[普罗布考的抗动脉粥样硬化作用机制]
Nihon Rinsho. 1999 Dec;57(12):2831-6.
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Dissociating HDL cholesterol from cardiovascular risk.将高密度脂蛋白胆固醇与心血管风险分离开来。
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Probucol alleviates atherosclerosis and improves high density lipoprotein function.普罗布考可减轻动脉粥样硬化并改善高密度脂蛋白功能。
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Probucol normalizes cholesteryl ester transfer in IDDM.普罗布考可使胰岛素依赖型糖尿病患者的胆固醇酯转运正常化。
Diabetes Care. 1995 Oct;18(10):1341-6. doi: 10.2337/diacare.18.10.1341.
7
[Probucol].[普罗布考]
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High-density lipoproteins from probucol-treated patients have increased capacity to promote cholesterol efflux from mouse peritoneal macrophages loaded with acetylated low-density lipoproteins.来自普罗布考治疗患者的高密度脂蛋白促进胆固醇从负载乙酰化低密度脂蛋白的小鼠腹腔巨噬细胞流出的能力增强。
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Circulation. 2019 Nov 5;140(19):1578-1589. doi: 10.1161/CIRCULATIONAHA.119.042551. Epub 2019 Sep 2.

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Effect of Probucol and Atorvastatin Treatment on the Self-Care Ability of Acute Cerebral Infarction Patients: A Randomized Clinical Trial Study.普罗布考与阿托伐他汀治疗对急性脑梗死患者自我护理能力的影响：一项随机临床试验研究。
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Probucol will become a new model for treating cerebral infarction with a high risk of hemorrhage: A narrative review.普罗布考将成为治疗高出血风险脑梗死的新模式：一篇叙述性综述。
Brain Circ. 2023 Nov 30;9(4):222-227. doi: 10.4103/bc.bc_44_23. eCollection 2023 Oct-Dec.
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The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases.普罗布考及其类似物在神经退行性疾病中的治疗潜力。
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本文引用的文献

1
Probucol Trial for Secondary Prevention of Atherosclerotic Events in Patients with Coronary Heart Disease (PROSPECTIVE).普罗布考用于冠心病患者二级预防动脉粥样硬化事件的试验（前瞻性）。
J Atheroscler Thromb. 2021 Feb 1;28(2):103-123. doi: 10.5551/jat.55327. Epub 2020 Apr 24.
2
Effects of high-density lipoprotein targeting treatments on cardiovascular outcomes: A systematic review and meta-analysis.靶向高密度脂蛋白治疗对心血管结局的影响：系统评价和荟萃分析。
Eur J Prev Cardiol. 2019 Mar;26(5):533-543. doi: 10.1177/2047487318816495. Epub 2018 Dec 6.
3
Effects of probucol on restenosis after percutaneous coronary intervention: a systematic review and meta-analysis.普罗布考对经皮冠状动脉介入术后再狭窄的影响：一项系统评价和荟萃分析。
PLoS One. 2015 Apr 21;10(4):e0124021. doi: 10.1371/journal.pone.0124021. eCollection 2015.
4
Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials.男性和女性的 LDL 降低治疗的疗效和安全性：27 项随机试验中 174000 名参与者的个体数据汇总分析。
Lancet. 2015 Apr 11;385(9976):1397-405. doi: 10.1016/S0140-6736(14)61368-4. Epub 2015 Jan 9.
5
Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan.长期普罗布考治疗可预防继发性心血管事件：日本杂合子家族性高胆固醇血症患者的队列研究。
J Atheroscler Thromb. 2008 Dec;15(6):292-303. doi: 10.5551/jat.e610. Epub 2008 Dec 6.
6
Probucol enhances the expression of human hepatic scavenger receptor class B type I, possibly through a species-specific mechanism.普罗布考可能通过一种物种特异性机制增强人肝脏I型B类清道夫受体的表达。
Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2422-7. doi: 10.1161/01.ATV.0000185834.98941.3d. Epub 2005 Sep 8.
7
The effect of probucol on femoral atherosclerosis: the Probucol Quantitative Regression Swedish Trial (PQRST).普罗布考对股动脉粥样硬化的影响：普罗布考定量回归瑞典试验（PQRST）。
Am J Cardiol. 1994 Nov 1;74(9):875-83. doi: 10.1016/0002-9149(94)90579-7.
8
A novel mechanism by which probucol lowers low density lipoprotein levels demonstrated in the LDL receptor-deficient rabbit.普罗布考降低低密度脂蛋白水平的一种新机制在低密度脂蛋白受体缺陷兔中得到证实。
J Lipid Res. 1984 Nov;25(11):1206-13.
9
Probucol inhibits oxidative modification of low density lipoprotein.普罗布考抑制低密度脂蛋白的氧化修饰。
J Clin Invest. 1986 Feb;77(2):641-4. doi: 10.1172/JCI112349.
10
Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.普罗布考可阻止渡边遗传性高脂血症兔（一种家族性高胆固醇血症动物模型）动脉粥样硬化的进展。
Proc Natl Acad Sci U S A. 1987 Aug;84(16):5928-31. doi: 10.1073/pnas.84.16.5928.