Bhaduri Utsa, Merla Giuseppe
Division of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (Foggia), Italy.
PhD Programme in Molecular Biomedicine, Department of Life Sciences, University of Trieste, Trieste, Italy.
Mol Ther Nucleic Acids. 2020 Sep 2;22:434-444. doi: 10.1016/j.omtn.2020.08.034. eCollection 2020 Dec 4.
The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is known to play a dual role as both tumor suppressor and oncogene, and to function at the crosstalk of cancer and innate immunity. In this review, in addition to accumulating recent corroborations that endorse this dual character of TRIM8, we appraise the game-changing capacity of TRIM8 under stress conditions against the backdrop of cell proliferation, apoptosis, and cancer, and also highlight the duality of TRIM8 in multiple contexts like cellular localization, stress-induced conditions, and E3 ubiquitin ligase activity. Finally, we discuss the emerging role of TRIM8 during bipolar spindle formation and mitotic progression, and its growing sphere of influence across multiple human cancers and pathologies, and suggest TRIM8-linked axes that can be modulated further for anti-cancer therapeutics development.
人含三联基序蛋白8（TRIM8）是TRIM家族蛋白成员，已知其兼具肿瘤抑制因子和癌基因的双重作用，并在癌症与先天免疫的相互作用中发挥功能。在本综述中，除了积累近期支持TRIM8这种双重特性的确证外，我们还在细胞增殖、凋亡和癌症的背景下评估了应激条件下TRIM8改变局面的能力，并且强调了TRIM8在细胞定位、应激诱导条件和E3泛素连接酶活性等多种情况下的双重性。最后，我们讨论了TRIM8在双极纺锤体形成和有丝分裂进程中的新作用，及其在多种人类癌症和病理状况中不断扩大的影响范围，并提出了可进一步调节以开发抗癌疗法的TRIM8相关轴。
