Department of Neurology, Federal University of the State of Rio de Janeiro, Mariz and Barros street, 775, Tijuca, Rio de Janeiro, RJ, 202709-001, Brazil.
Department of Public Health, University of Brandenburg of Technology Cottbus, Senftenberg, Germany.
Neurol Sci. 2021 Apr;42(4):1545-1548. doi: 10.1007/s10072-020-04908-2. Epub 2020 Nov 23.
Celiac disease (CD) is an immune-mediated systemic disorder triggered by gluten and related prolamins in genetically predisposed individuals. Here, we described a case of a 31-year-old Caucasian woman who exhibited cerebellar and psychiatric dysfunctions. The patient underwent single-photon emission computed tomography (SPECT-CT) before and after a gluten-free diet (GFD). There was an improvement in cerebellar perfusion accompanied by a remission of cerebellar manifestations. The maintenance of the psychiatric manifestations was related to the persistence of the hypoperfusion in the frontal lobes. The patient's psychiatric symptoms did not change after 4 months under a GFD in the hospital. To our knowledge, this is the first case that shows the relationship between improvement in cerebellar perfusion and remission of cerebellar clinical manifestations in a CD patient under a GFD.
乳糜泻（CD）是一种由遗传易感性个体中的麸质和相关醇溶蛋白引发的免疫介导的系统性疾病。在这里，我们描述了一例 31 岁的高加索女性，其表现为小脑和精神功能障碍。该患者在进行无麸质饮食（GFD）前后接受了单光子发射计算机断层扫描（SPECT-CT）。小脑灌注得到改善，同时小脑表现也得到缓解。精神表现的维持与额叶灌注不足的持续存在有关。在医院进行 GFD 4 个月后，患者的精神症状没有改变。据我们所知，这是首例显示 CD 患者在 GFD 下小脑灌注改善与小脑临床表现缓解之间关系的病例。
