99mTc-2,3-二氨基丙酸络合物作为肾功能显像剂：与99mTc-DTPA和131I-OIH生物学特性的比较
99mTc-2,3-diaminopropionic acid complex as renal function agent: comparison of biological properties with 99mTc-DTPA and 131I-OIH.
作者信息
Chattopadhyay M, Jalan K N, Pal A K, Banerjee S N
机构信息
Indian Institute of Chemical Biology, Calcutta.
出版信息
Int J Rad Appl Instrum B. 1987;14(6):599-604. doi: 10.1016/0883-2897(87)90032-8.
The preparation, purification, biodistribution, blood disappearance kinetics and imaging characteristics of 99mTc-2,3-diamino propionic acid (99m-Tc-DAPA) is studied. The latter three studies were conducted on rabbits as the experimental animal and the data thus obtained were compared with 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) and 131I-orthoiodohippurate (131I-OIH) with a view to find a possible replacement of the latter radiopharmaceutical with a more convenient 99mTc based compound. Preliminary data indicates favourable results for 99mTc-2,3-diamino propionic acid which warrants further investigation.
研究了99mTc-2,3-二氨基丙酸（99mTc-DAPA）的制备、纯化、生物分布、血液清除动力学及显像特性。后三项研究以兔作为实验动物进行，所得数据与99mTc-二乙三胺五乙酸（99mTc-DTPA）和131I-邻碘马尿酸（131I-OIH）进行比较，以期用更便捷的基于99mTc的化合物替代后一种放射性药物。初步数据表明99mTc-2,3-二氨基丙酸取得了良好结果，值得进一步研究。
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