Institute fur Biochemie, University of Greifswald, Felix-Hausdorff-Strasse 4, D-17487, Greifswald, Germany.
Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh road, Matunga, Mumbai, 400019, India.
Chem Rec. 2021 Jan;21(1):188-203. doi: 10.1002/tcr.202000109. Epub 2020 Nov 24.
Phosphines have, in combination with transition metals, played a pivotal role in the rapid development of efficient catalytic processes. Caged phosphines constitute a class of three-dimensional scaffolds providing unique control over steric and electronic properties. The versatility of the caged phosphine ligands has been demonstrated elegantly by the groups of Verkade, Gonzalvi as well as Stradiotto. Our research group has also been working extensively for the past several years in the development of 1,3,5-triaza-7-phosphaadamantane-based caged ligands and in this personal note we have summarized these applications pertaining to the modification of biologically useful nucleosides and heteroarenes.
膦与过渡金属相结合，在高效催化过程的快速发展中发挥了关键作用。笼状膦构成了一类提供对空间和电子性质的独特控制的三维支架。Verkade、Gonzalvi 和 Stradiotto 等人的小组优雅地展示了笼状膦配体的多功能性。我们的研究小组在过去几年中也一直在广泛开发基于 1,3,5-三氮杂-7-磷杂金刚烷的笼状配体，在这篇个人笔记中，我们总结了这些应用于修饰生物有用的核苷和杂芳烃。
