Meyers P A
Department of Pediatrics, Cornell University Medical College, New York, New York.
Hematol Oncol Clin North Am. 1987 Dec;1(4):655-65.
Osteosarcoma is a rare malignant tumor of bone that produces osteoid. Most tumors arise in the metaphyses of long bones. At least 80 per cent of patients have subclinical metastases at diagnosis. Successful management of osteosarcoma requires surgical control of the primary tumor and chemotherapeutic control of systemic metastases. Wide resection of primary tumor is often compatible with limb-sparing surgery. Multiagent chemotherapy has significantly enhanced disease-free survival. Osteosarcoma metastasizes to lung and other bones. Aggressive surgical resection can sometimes control pulmonary metastases; bony metastases are almost always followed by death.
骨肉瘤是一种罕见的产生骨样组织的恶性骨肿瘤。大多数肿瘤发生在长骨的干骺端。至少80%的患者在诊断时已有亚临床转移。骨肉瘤的成功治疗需要对原发性肿瘤进行手术控制以及对全身转移进行化疗控制。原发性肿瘤的广泛切除通常与保肢手术兼容。多药化疗显著提高了无病生存率。骨肉瘤转移至肺和其他骨骼。积极的手术切除有时可控制肺转移；骨转移几乎总会导致死亡。
