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儿童布加综合征伴急性广泛内脏静脉系统血栓形成和经颈静脉肝内门体分流术血栓形成的术前成功取栓和溶栓——为活体肝移植创造机会。

Preoperative successful thrombectomy and thrombolysis of acute extensive splanchnic venous system and TIPSS thrombosis in a child with Budd-Chiari syndrome-Creating a window to enable living donor liver transplantation.

机构信息

Department of Hepatology, Apollo Hospitals, Navi Mumbai, India.

Department of Liver Transplantation and HPB Surgery, Apollo Hospitals, Navi Mumbai, India.

出版信息

Pediatr Transplant. 2021 May;25(3):e13857. doi: 10.1111/petr.13857. Epub 2020 Nov 24.

Abstract

Preoperative extensive PV thrombosis can pose a technical challenge during liver transplantation surgery. Several strategies adopted to mitigate this problem include creation of a superior mesenteric vein-PV jump graft, use of a polytetrafluoroethylene graft, renoportal anastomosis, or cavoportal hemitransposition. Extensive and diffuse thrombosis of the splanchnic venous system may even necessitate multivisceral transplantation. We describe the case of a pediatric patient with Budd-Chiari syndrome and decompensated cirrhosis, who developed extensive thrombosis of the porto-spleno-mesenteric venous system prior to liver transplantation. We used a combination technique of thrombus aspiration by a novel trans-TIPPS approach followed by thrombolysis. Complete preoperative resolution of the extensive thrombosis was achieved. This allowed the creation of a brief window to enable planned LDLT. In prudently selected patients, performing an early mechanical and chemical thrombolysis of an extensive acute splanchnic venous thrombosis can thus help expedite a planned LDLT.

摘要

术前广泛的门静脉血栓形成可能在肝移植手术中带来技术挑战。为了减轻这个问题,我们采用了几种策略,包括创建肠系膜上静脉-门静脉跳跃移植物、使用聚四氟乙烯移植物、肾门静脉吻合术或腔静脉半转位术。广泛弥漫性的内脏静脉系统血栓形成甚至可能需要进行多脏器移植。我们描述了一例小儿布加综合征和失代偿性肝硬化患者的病例,该患者在肝移植前发生了广泛的门腔静脉系统血栓形成。我们采用了一种新型经颈静脉肝内门体分流术(TIPPS)联合血栓抽吸和溶栓的治疗方法。术前广泛的血栓完全溶解。这为创建一个简短的窗口期以进行计划的 LDLT 提供了可能。因此,在谨慎选择的患者中,对广泛的急性内脏静脉血栓形成进行早期机械和化学溶栓可以帮助加快计划的 LDLT。

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