Leebeek F W, Lameris J S, van Buuren H R, Gomez E, Madretsma S, Sonneveld P
Department of Haematology, University Hospital Rotterdam Dijkzigt, The Netherlands.
Br J Haematol. 1998 Sep;102(4):929-31. doi: 10.1046/j.1365-2141.1998.00860.x.
We present the first case of Budd-Chiari syndrome in association with portal and mesenteric vein thrombosis in a patient homozygous for the factor V Leiden mutation. She was treated by transjugular intrahepatic portosystemic stent (TIPS) placement followed by local thrombolytic therapy. Venous outflow from the liver was established and the thrombi in the portal and mesenteric veins were lysed completely. This therapeutic approach may be used for such patients with this severe thrombotic event, who generally have a poor prognosis.
我们报告了首例患有因子V莱顿突变纯合子的患者发生布加综合征合并门静脉和肠系膜静脉血栓形成的病例。她接受了经颈静脉肝内门体分流术（TIPS）置入，随后进行局部溶栓治疗。肝脏的静脉流出道得以建立，门静脉和肠系膜静脉内的血栓被完全溶解。这种治疗方法可用于患有这种严重血栓形成事件的患者，这类患者通常预后较差。
