Educational and Research Institute, Barretos Cancer Hospital, R. Antenor Duarte Villela, 1331, Barretos, SP, CEP: 14784-400, Brazil.
Institute for Risk Assessment Sciences, Utrecht University, P.O. Box 80178, 3508 TD Utrecht, the Netherlands.
Cancer Epidemiol. 2021 Feb;70:101859. doi: 10.1016/j.canep.2020.101859. Epub 2020 Nov 23.
Despite widespread evidence that air pollution is carcinogenic, there is little evidence from low-middle income countries, especially related to childhood malignancies. We examined the role of traffic related pollution on lymphohematopoietic malignancies among under-14 s in Sao Paulo.
All incident cases between 2002 and 2011 were collected from a population-based registry. Exposures were assigned on residential address at diagnosis via traffic density database (for the year 2008) and a satellite derived NO land use regression model (averaged between 1997 and 2011). Incidence rate ratios (IRRs) were calculated via Poisson Regression adjusted by age, gender and socioeconomic status (SES), with additional stratification by SES.
A positive association between traffic and NO with some lymphohematopoietic malignancies was observed with the degree of effect differing by SES. For example, lymphoid leukemia IRRs in the lower SES group were 1.21 (95 % CI: 1.06, 1.39) for traffic density and 1.38 (95 % CI: 1.13, 1.68) for NO. In the higher group they were 1.06 (95 % CI: 1.00, 1.14) and 1.37 (95 % CI: 1.16, 1.62).
NO and traffic density were associated with Hodgkin lymphoma and lymphoid leukemia among children in São Paulo. Differing IRRs by gender and SES group indicate differences in underlying risk and/or exposure profiles.
尽管有广泛的证据表明空气污染具有致癌性，但来自中低收入国家的证据很少，特别是与儿童恶性肿瘤相关的证据。我们研究了圣保罗市 14 岁以下儿童中与交通相关的污染对淋巴血液系统恶性肿瘤的作用。
所有 2002 年至 2011 年间的发病病例均来自一个基于人群的登记处。通过交通密度数据库（针对 2008 年）和基于卫星的 NO 土地利用回归模型（1997 年至 2011 年平均），按诊断时的居住地址为暴露赋值。通过泊松回归计算发病率比（IRR），并按年龄、性别和社会经济状况（SES）进行调整，同时按 SES 进行分层。
观察到交通和 NO 与某些淋巴血液系统恶性肿瘤之间存在正相关关系，其影响程度因 SES 而异。例如，在 SES 较低的组中，淋巴样白血病的 IRR 分别为交通密度的 1.21（95%CI：1.06，1.39）和 NO 的 1.38（95%CI：1.13，1.68）。在 SES 较高的组中，IRR 分别为 1.06（95%CI：1.00，1.14）和 1.37（95%CI：1.16，1.62）。
NO 和交通密度与圣保罗儿童的霍奇金淋巴瘤和淋巴样白血病有关。性别和 SES 组的 IRR 差异表明潜在风险和/或暴露特征存在差异。
