Soares Lucas Weba, Bailão Alexandre Melo, Soares Célia Maria de Almeida, Bailão Mirelle Garcia Silva
Departamento de Bioquímica e Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia 74690-900, Goiás, Brazil.
J Fungi (Basel). 2020 Nov 21;6(4):305. doi: 10.3390/jof6040305.
Zinc is an essential nutrient for all living organisms. However, firm regulation must be maintained since micronutrients also can be toxic in high concentrations. This notion is reinforced when we look at mechanisms deployed by our immune system, such as the use of chelators or membrane transporters that capture zinc, when threatened with pathogens, like fungi. Pathogenic fungi, on the other hand, also make use of a variety of transporters and specialized zinc captors to survive these changes. In this review, we sought to explain the mechanisms, grounded in experimental analysis and described to date, utilized by pathogenic fungi to maintain optimal zinc levels.
锌是所有生物必需的营养素。然而，由于微量营养素在高浓度时也可能有毒，因此必须保持严格的调节。当我们审视我们的免疫系统所采用的机制时，这一观点得到了强化，例如在受到真菌等病原体威胁时，利用螯合剂或捕获锌的膜转运蛋白。另一方面，致病真菌也利用各种转运蛋白和专门的锌捕获器来在这些变化中生存。在这篇综述中，我们试图解释基于实验分析且迄今已描述的致病真菌用于维持最佳锌水平的机制。
