Schmähl D
Cancer. 1977 Oct;40(4 Suppl):1927-9. doi: 10.1002/1097-0142(197710)40:4+<1927::aid-cncr2820400825>3.0.co;2-s.
Some anticancer drugs, especially alkylating agents, have under certain conditions shown a carcinogenic effect in animals, as well as in man. This carcinogenic effect is not due to the immunosuppressive properties of these substances but is directly related to their physicochemical properties. In extensive experimental studies with rats, a connection between the immune status of the host organism and the chemical carcinogenesis could not be proved.
一些抗癌药物，尤其是烷化剂，在某些条件下已在动物以及人类中显示出致癌作用。这种致癌作用并非由于这些物质的免疫抑制特性，而是与其物理化学性质直接相关。在对大鼠进行的广泛实验研究中，未能证明宿主生物体的免疫状态与化学致癌作用之间存在关联。
