Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan 430071, China.
Information Management and Information System, School of Medical and Health Management, Huazhong University of Science and Technology, Wuhan 430030, China.
Int J Environ Res Public Health. 2020 Nov 20;17(22):8628. doi: 10.3390/ijerph17228628.
Persuasive evidence has shown the inverse associations between physical activity (PA) and the risk of stroke. However, few studies have investigated the associations between different dimensions (intensity, frequency, duration, volume) of PA and the risk of stroke.
To investigate the associations between different dimensions of PA and the risk of stroke in total participants and subgroups.
This study included 6250 individuals aged 45 years old and above from the China Health and Retirement Longitudinal Study (CHARLS). PA was divided into vigorous PA (VPA), moderate PA (MPA), and light PA (LPA), and described in different dimensions (intensity, frequency, duration, volume). Stroke was defined on the basis of self-reported diagnosis and related treatments. Binary logistic regression models were established to assess the associations between different dimensions of PA and the risk of stroke in total participants and subgroups stratified by sex.
Individuals taking VPA with a frequency of 3-5 d/w, duration of ≥240 min/d, volume of ≥300 min/w had lower risks of strokes in total participants (Odds ratio (OR) = 0.32, 95% confidence interval (CI): 0.13, 0.75; OR = 0.60, 95% CI: 0.38, 0.94; OR = 0.68, 95% CI: 0.46, 0.99, respectively). However, significant associations of VPA with the risk of stroke in men were only observed in the duration of ≥240 min/d and volume of ≥300 min/w (OR = 0.53, 95% CI: 0.30, 0.93; OR = 0.61, 95% CI: 0.38, 0.99, respectively) whereas no significance in women. Compared with individuals taking no MPA, inverse significant associations between the risk of stroke and any level of frequency, duration and volume in MPA were observed in total sample (OR ranging from 0.16-0.40, all < 0.05), whereas significant associations between the risk of stroke and MPA were found in men except the duration of 10-29 min/d and volume of 150-299 min/w (OR ranging from 0.26-0.35, all < 0.05), and in women except the frequency of 1-2 d/w and duration of ≥240 min/d (OR ranging from 0.14-0.49, all < 0.05). No significant associations could be observed in total participants and subgroups between LPA and the risk of stroke.
This study revealed some significant associations between different dimensions of PA, especially MPA, and the risk of stroke. Furthermore, the difference of association was observed in the groups with different sex. Further prospective study is needed to determine deeper associations between PA and the risk of stroke.
已有大量证据表明，身体活动（PA）与中风风险呈负相关。然而，很少有研究调查不同维度（强度、频率、持续时间、量）的 PA 与中风风险之间的关系。
在总人群和亚组中，研究不同维度的 PA 与中风风险之间的关系。
本研究纳入了来自中国健康与退休纵向研究（CHARLS）的 6250 名年龄在 45 岁及以上的个体。PA 分为剧烈 PA（VPA）、中度 PA（MPA）和轻度 PA（LPA），并以不同维度（强度、频率、持续时间、量）来描述。中风是根据自我报告的诊断和相关治疗来定义的。采用二元逻辑回归模型评估总人群及按性别分层的亚组中不同维度的 PA 与中风风险之间的关系。
在总人群中，每周进行 3-5 天、每次持续时间≥240 分钟、每周累计量≥300 分钟的 VPA 与中风风险降低相关（比值比（OR）=0.32，95%置信区间（CI）：0.13，0.75；OR=0.60，95%CI：0.38，0.94；OR=0.68，95%CI：0.46，0.99，分别）。然而，仅在男性中观察到 VPA 与中风风险的关联在持续时间≥240 分钟/天和量≥300 分钟/周时具有统计学意义（OR=0.53，95%CI：0.30，0.93；OR=0.61，95%CI：0.38，0.99，分别），而在女性中则无统计学意义。与不进行任何 MPA 的个体相比，在总样本中，任何水平的 MPA 的频率、持续时间和量均与中风风险呈负相关（OR 范围为 0.16-0.40，均<0.05），而在男性中，除了持续时间为 10-29 分钟/天和量为 150-299 分钟/周外，与中风风险的关联具有统计学意义（OR 范围为 0.26-0.35，均<0.05），在女性中，除了频率为 1-2 天/周和持续时间≥240 分钟/天外，与中风风险的关联具有统计学意义（OR 范围为 0.14-0.49，均<0.05）。在总人群和亚组中，LPA 与中风风险之间未观察到显著关联。
本研究揭示了不同维度的 PA（尤其是 MPA）与中风风险之间的一些显著关联。此外，在不同性别组中观察到关联的差异。需要进一步的前瞻性研究来确定 PA 与中风风险之间的更深层次关系。
Zotero 插件
