静脉注射氢化可的松治疗难治性新生儿惊厥的疗效：三例报告
Efficacy of Intravenous Hydrocortisone Treatment in Refractory Neonatal Seizures: A Report on Three Cases.
作者信息
Di Rosa Gabriella, Dicanio Daniela, Nicotera Antonio Gennaro, Mondello Patrizia, Cannavò Laura, Gitto Eloisa
机构信息
Unit of Child Neurology and Psychiatry, Department of Human Pathology of the Adult and Developmental Age, "Gaetano Barresi" University of Messina, 98125 Messina, Italy.
Unit of Hematology, Department of Human Pathology of the Adult and Developmental Age, "Gaetano Barresi" University of Messina, 98125 Messina, Italy.
出版信息
Brain Sci. 2020 Nov 20;10(11):885. doi: 10.3390/brainsci10110885.
Neonatal seizures are the most common neurological emergency, and neonatal status epilepticus (NSE) remains a controversial entity, with no general consensus about its definition and treatment. Here, we report on three newborns with NSE refractory to first- and second-line antiepileptic drugs successfully treated with intravenous (IV) hydrocortisone. The patients had previously failed therapy with levetiracetam, phenobarbital and midazolam, showing persistent clinical and electrical seizures. Modulation of brain inflammation triggered during prolonged epileptic activity has been thought to potentially explain the beneficial effects of anti-inflammatory treatment.
新生儿惊厥是最常见的神经急症，而新生儿癫痫持续状态（NSE）仍是一个存在争议的实体，关于其定义和治疗尚无普遍共识。在此，我们报告3例NSE新生儿，他们对一线和二线抗癫痫药物难治，经静脉注射氢化可的松成功治疗。这些患者先前使用左乙拉西坦、苯巴比妥和咪达唑仑治疗失败，仍有持续的临床和电惊厥发作。长期癫痫活动引发的脑炎症调节被认为可能解释抗炎治疗的有益效果。
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