针对宿主的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）基因组编辑
Host-directed editing of the SARS-CoV-2 genome.
作者信息
Mourier Tobias, Sadykov Mukhtar, Carr Michael J, Gonzalez Gabriel, Hall William W, Pain Arnab
机构信息
King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE), Thuwal-Jeddah, 23955-6900, Saudi Arabia.
King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE), Thuwal-Jeddah, 23955-6900, Saudi Arabia.
出版信息
Biochem Biophys Res Commun. 2021 Jan 29;538:35-39. doi: 10.1016/j.bbrc.2020.10.092. Epub 2020 Nov 5.
The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
2020年疫情期间从严重急性呼吸综合征冠状病毒2（SARS-CoV-2）产生的大量序列数据，有助于在短时间内研究病毒基因组的进化。这突出了宿主抗病毒防御系统对SARS-CoV-2基因组施加定向突变压力的实例。在这篇简短的综述中，我们描述了三种这样的人体防御机制，即载脂蛋白B信使核糖核酸编辑催化多肽样蛋白（APOBEC）、作用于RNA的腺苷脱氨酶（ADAR）和活性氧（ROS），并讨论它们对SARS-CoV-2进化的潜在影响。
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