Zaug A J, Cech T R
Department of Chemistry and Biochemistry, University of Colorado, Boulder, 80309-0215.
J Protozool. 1987 Nov;34(4):416-7. doi: 10.1111/j.1550-7408.1987.tb03204.x.
The RNA molecules transcribed from many eukaryotic genes are interrupted by intervening sequences, which are removed by a process called RNA splicing. One structurally related group of intervening sequences, the group I intervening sequences, are found in a variety of microorganisms. Some of these, including the group I intervening sequence from the ribosomal RNA precursor of Tetrahymena thermophila, have been shown to mediate their own splicing in an RNA-catalyzed reaction. Following its excision from the ribosomal RNA precursor, the Tetrahymena intervening sequence acts as an enzyme, cutting and rejoining RNA substrates.
许多真核基因转录出的RNA分子会被间隔序列打断，这些间隔序列通过一个称为RNA剪接的过程被去除。一类结构相关的间隔序列，即I类间隔序列，存在于多种微生物中。其中一些，包括嗜热四膜虫核糖体RNA前体中的I类间隔序列，已被证明能在RNA催化的反应中介导自身的剪接。从核糖体RNA前体中切除后，嗜热四膜虫间隔序列充当一种酶，切割并连接RNA底物。
