Division of Neonatology, Connecticut Children's Medical Center, Hartford, CT, USA.
Department of Pediatrics, Universityof Connecticut School of Medicine, Farmington, CT, USA.
J Perinatol. 2021 Sep;41(9):2147-2155. doi: 10.1038/s41372-020-00870-1. Epub 2020 Nov 24.
Pre-pregnancy or first trimester biomarkers predicting preterm delivery are lacking. The purpose of this study was to determine whether maternal H-antigen (secretor status) is a potential biomarker for preterm delivery.
This cohort study examined maternal saliva samples and birth data gathered by the National Children's Study Vanguard pilot phase (2009-2014) and included 300 women who were ≥18 years old and provided birth data and saliva samples. The maternal secretor status phenotype was determined by quantifying H-antigen in saliva using enzyme-linked immunoassay. Mothers were stratified by secretor status and multivariable analysis estimated adjusted associations with preterm delivery.
Maternal lack of H-antigen production was an independent risk factor for preterm delivery after adjusting for known confounders (aOR 4.53; 95% CI: 1.74, 11.81; P = 0.002).
Maternal H-antigen may be a biomarker identifying women at-risk for preterm delivery. Prospective cohort studies validating these findings are needed.
缺乏预测早产的孕前或早孕期生物标志物。本研究旨在确定母体 H 抗原（分泌状态）是否是早产的潜在生物标志物。
本队列研究检测了国家儿童研究先锋阶段（2009-2014 年）收集的 300 名年龄≥18 岁且提供了分娩数据和唾液样本的孕妇的唾液样本和分娩数据。通过使用酶联免疫吸附试验定量唾液中的 H 抗原来确定母体分泌状态表型。根据分泌状态对母亲进行分层，多变量分析估计了与早产相关的调整关联。
在调整了已知混杂因素后，母体缺乏 H 抗原产生是早产的独立危险因素（调整后的优势比 4.53；95%置信区间：1.74，11.81；P=0.002）。
母体 H 抗原可能是识别早产风险妇女的生物标志物。需要前瞻性队列研究来验证这些发现。
