• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

血清可溶性Toll样受体2和4作为非霍奇金淋巴瘤的诊断和预后生物标志物

Serum soluble toll-like receptor 2 and 4 as diagnostic and prognostic biomarkers for non-Hodgkin lymphoma.

作者信息

Fakhry Nouran, Gowily Ahmed, Okda Tarek, Houssen Maha

机构信息

Department of Biochemistry, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.

Department of Clinical Oncology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

出版信息

Contemp Oncol (Pozn). 2020;24(3):157-162. doi: 10.5114/wo.2020.100270. Epub 2020 Oct 30.

DOI:10.5114/wo.2020.100270
PMID:33235541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7670186/
Abstract

AIM OF THE STUDY

To assess the serum levels of soluble toll-like receptor 2 (sTLR2) and soluble toll-like receptor 4 (sTLR4) in a group of patients with non-Hodgkin lymphoma (NHL) and to investigate their correlations with the clinicopathological parameters of NHL.

MATERIAL AND METHODS

Fifty patients with early-stage NHL and 50 patients with advanced-stage NHL along with 50 age- and sex-matched healthy volunteers were enrolled in the study. Serum levels of sTLR2 and sTLR4 were measured using enzyme-linked immunosorbent assay (ELISA).

RESULTS

A significant increase in the serum levels of sTLR2 (pg/ml) was detected in early stage NHL (group I) (2381.1 ±1822.0) and advanced stage NHL (group II) (2864.9 ±2599.9) when compared to levels in the control group (1229.2 ±70.55) ( < 0.001). A significant increase in the serum levels of sTLR4 (pg/ml) was detected in early stage NHL (2465.4 ±3501.8) and advanced stage NHL (4759.7 ±5176.2) when compared to levels in the control group (1242.3 ±53) ( < 0.001). A significant positive correlation was detected between the serum levels of both sTLR2 and sSTLR4 and the Ann Arbor staging of NHL.

CONCLUSIONS

sTLR2 and sTLR4 might be diagnostic and prognostic biomarkers for NHL.

摘要

研究目的

评估一组非霍奇金淋巴瘤（NHL）患者血清中可溶性Toll样受体2（sTLR2）和可溶性Toll样受体4（sTLR4）的水平，并研究它们与NHL临床病理参数的相关性。

材料与方法

本研究纳入50例早期NHL患者、50例晚期NHL患者以及50例年龄和性别匹配的健康志愿者。采用酶联免疫吸附测定（ELISA）法检测血清中sTLR2和sTLR4的水平。

结果

与对照组（1229.2±70.55）相比，早期NHL（I组）（2381.1±1822.0）和晚期NHL（II组）（2864.9±2599.9）患者血清中sTLR2（pg/ml）水平显著升高（P<0.001）。与对照组（1242.3±53）相比，早期NHL（2465.4±3501.8）和晚期NHL（4759.7±5176.2）患者血清中sTLR4（pg/ml）水平显著升高（P<0.001）。sTLR2和sTLR4的血清水平与NHL的Ann Arbor分期之间存在显著正相关。

结论

sTLR2和sTLR4可能是NHL的诊断和预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/a833909e6e40/WO-24-42187-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/d9d98ab3a9c0/WO-24-42187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/2723385d87a1/WO-24-42187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/a73c441ce435/WO-24-42187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/5558cff47bc4/WO-24-42187-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/500a11194337/WO-24-42187-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/57f03d017aed/WO-24-42187-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/a833909e6e40/WO-24-42187-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/d9d98ab3a9c0/WO-24-42187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/2723385d87a1/WO-24-42187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/a73c441ce435/WO-24-42187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/5558cff47bc4/WO-24-42187-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/500a11194337/WO-24-42187-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/57f03d017aed/WO-24-42187-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/678a/7670186/a833909e6e40/WO-24-42187-g007.jpg

相似文献

1
Serum soluble toll-like receptor 2 and 4 as diagnostic and prognostic biomarkers for non-Hodgkin lymphoma.血清可溶性Toll样受体2和4作为非霍奇金淋巴瘤的诊断和预后生物标志物
Contemp Oncol (Pozn). 2020;24(3):157-162. doi: 10.5114/wo.2020.100270. Epub 2020 Oct 30.
2
Association between serum soluble Toll-like receptor 2 and 4 and the risk of breast cancer.血清可溶性Toll样受体2和4与乳腺癌风险之间的关联。
Mol Clin Oncol. 2021 Feb;14(2):38. doi: 10.3892/mco.2020.2200. Epub 2020 Dec 24.
3
Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions.HIV/SIV相关神经病理状况下脑脊液中可溶性TLR2和4的浓度
J Neurovirol. 2017 Apr;23(2):250-259. doi: 10.1007/s13365-016-0495-7. Epub 2016 Nov 23.
4
The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases.可溶性Toll样受体（sTLR）2和sTLR4在炎症性疾病中的鉴别能力。
BMC Immunol. 2014 Nov 19;15:55. doi: 10.1186/s12865-014-0055-y.
5
Serum soluble Toll-like receptor 4 and the risk of hepatocellular carcinoma in hepatitis C virus patients.血清可溶性Toll样受体4与丙型肝炎病毒患者肝细胞癌风险
Contemp Oncol (Pozn). 2020;24(4):216-220. doi: 10.5114/wo.2020.102818. Epub 2021 Jan 4.
6
The association between TLR2/4 and clinical outcome in intracerebral hemorrhage.TLR2/4与脑出血临床结局之间的关联。
Clin Neurol Neurosurg. 2024 Sep;244:108440. doi: 10.1016/j.clineuro.2024.108440. Epub 2024 Jul 8.
7
Serum concentration and mRNA expression in milk somatic cells of toll-like receptor 2, toll-like receptor 4, and cytokines in dairy cows following intramammary inoculation with Escherichia coli.奶牛经乳房内接种大肠杆菌后，血清浓度和乳体细胞中 toll 样受体 2、toll 样受体 4 和细胞因子的 mRNA 表达。
J Dairy Sci. 2011 Dec;94(12):5903-12. doi: 10.3168/jds.2011-4167.
8
Serum soluble toll-like receptor 2: a novel biomarker for systemic lupus erythematosus disease activity and lupus-related cardiovascular dysfunction.血清可溶性Toll样受体2：系统性红斑狼疮疾病活动度及狼疮相关心血管功能障碍的新型生物标志物。
Int J Rheum Dis. 2016 Jul;19(7):685-92. doi: 10.1111/1756-185X.12452. Epub 2014 Aug 14.
9
Associations Between Serum Soluble Toll-like Receptors 4 and 9 and Breast Cancer in Egyptian Patients.血清可溶性 Toll 样受体 4 和 9 与埃及患者乳腺癌的相关性研究。
Cancer Control. 2023 Jan-Dec;30:10732748231204755. doi: 10.1177/10732748231204755.
10
Soluble Toll-like receptor 4 is a potential serum biomarker in non-small cell lung cancer.可溶性Toll样受体4是非小细胞肺癌潜在的血清生物标志物。
Oncotarget. 2016 Jun 28;7(26):40106-40114. doi: 10.18632/oncotarget.9496.

引用本文的文献

1
Expression of Toll-like Receptors on Lymphocyte Subpopulations and Their Soluble Forms in Serum and Urine of Women with Endometriosis.子宫内膜异位症女性血清和尿液中淋巴细胞亚群上Toll样受体及其可溶性形式的表达
Cells. 2025 Aug 18;14(16):1273. doi: 10.3390/cells14161273.
2
Serum soluble toll-like receptor 4 and risk for clinical severity in COVID-19 patients.新冠病毒肺炎患者血清可溶性Toll样受体4水平与临床严重程度风险
Pneumonia (Nathan). 2024 Jan 5;16(1):1. doi: 10.1186/s41479-023-00121-9.
3
Alternative pre-mRNA splicing as a mechanism for terminating Toll-like Receptor signaling.

本文引用的文献

1
Toll-Like Receptors: Regulators of the Immune Response in the Human Gut.Toll 样受体：人类肠道中免疫反应的调节剂。
Nutrients. 2018 Feb 13;10(2):203. doi: 10.3390/nu10020203.
2
Toll-like receptors and their soluble forms differ in the knee and thumb basal osteoarthritic joints.Toll样受体及其可溶性形式在膝关节和拇指基底骨关节炎关节中存在差异。
Acta Orthop. 2017 Jun;88(3):326-333. doi: 10.1080/17453674.2017.1281058. Epub 2017 Jan 17.
3
Insights into Soluble Toll-Like Receptor 2 as a Downregulator of Virally Induced Inflammation.
可变剪接作为终止 Toll 样受体信号转导的一种机制。
Front Immunol. 2022 Dec 1;13:1023567. doi: 10.3389/fimmu.2022.1023567. eCollection 2022.
4
A Novel Role of Galectin-3 and Thyroglobulin in Prognosis and Differentiation of Different Stages of Thyroid Cancer and Elucidation of the Potential Contribution of Bcl-2, IL-8 and TNF-α.半乳糖凝集素-3和甲状腺球蛋白在甲状腺癌不同阶段的预后及分化中的新作用以及Bcl-2、IL-8和TNF-α潜在作用的阐明
Biomedicines. 2022 Feb 1;10(2):352. doi: 10.3390/biomedicines10020352.
可溶性Toll样受体2作为病毒诱导炎症的下调因子的研究进展
Front Immunol. 2016 Aug 2;7:291. doi: 10.3389/fimmu.2016.00291. eCollection 2016.
4
Soluble Toll-like receptor 4 is a potential serum biomarker in non-small cell lung cancer.可溶性Toll样受体4是非小细胞肺癌潜在的血清生物标志物。
Oncotarget. 2016 Jun 28;7(26):40106-40114. doi: 10.18632/oncotarget.9496.
5
The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases.可溶性Toll样受体（sTLR）2和sTLR4在炎症性疾病中的鉴别能力。
BMC Immunol. 2014 Nov 19;15:55. doi: 10.1186/s12865-014-0055-y.
6
Serum soluble toll-like receptor 2: a novel biomarker for systemic lupus erythematosus disease activity and lupus-related cardiovascular dysfunction.血清可溶性Toll样受体2：系统性红斑狼疮疾病活动度及狼疮相关心血管功能障碍的新型生物标志物。
Int J Rheum Dis. 2016 Jul;19(7):685-92. doi: 10.1111/1756-185X.12452. Epub 2014 Aug 14.
7
Toll-like receptor 2 and 9 genetic polymorphisms and the susceptibility to B cell Non-Hodgkin Lymphoma in Egypt.埃及人群中Toll样受体2和9基因多态性与B细胞非霍奇金淋巴瘤易感性的关系
Ann Hematol. 2014 Nov;93(11):1859-65. doi: 10.1007/s00277-014-2131-z. Epub 2014 Jun 10.
8
Toll-like receptors 3, 4 and 9 in hepatocellular carcinoma: Relationship with clinicopathological characteristics and prognosis.Toll 样受体 3、4 和 9 在肝细胞癌中的作用：与临床病理特征和预后的关系。
Hepatol Res. 2014 Jul;44(7):769-78. doi: 10.1111/hepr.12180. Epub 2013 Jul 10.
9
Toll-like receptors.Toll样受体
Curr Biol. 2011 Jul 12;21(13):R488-93. doi: 10.1016/j.cub.2011.05.039.
10
Differential expression of Toll-like receptors in follicular lymphoma, diffuse large B-cell lymphoma and peripheral T-cell lymphoma.Toll 样受体在滤泡性淋巴瘤、弥漫性大 B 细胞淋巴瘤和外周 T 细胞淋巴瘤中的差异表达。
Exp Mol Pathol. 2010 Dec;89(3):284-90. doi: 10.1016/j.yexmp.2010.08.003. Epub 2010 Aug 25.