匹可硫酸钠溶液用作结肠镜检查肠道清洁剂时引起低钠血症的频率。

Frequency of hyponatremia caused by sodium picosulfate solution when used as a bowel cleansing agent for colonoscopy.

作者信息

Rasheed Tazeen, Alvi Haris, Shaikh Majid Ahmed, Ali Faiza Sadaqat, Zuberi Bader Faiyaz, Subhan Wara

机构信息

Dr. Tazeen Rasheed, Assistant Professor, Dow University of Health Sciences, Karachi, Pakistan.

Prof. Haris Alvi, MBBS, FCPS. Dow University of Health Sciences, Karachi, Pakistan.

出版信息

Pak J Med Sci. 2020 Nov-Dec;36(7):1651-1654. doi: 10.12669/pjms.36.7.2376.

DOI:10.12669/pjms.36.7.2376

PMID:33235591

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7674881/

Abstract

OBJECTIVE

To determine the frequency of hyponatremia in patients taking Sodium Picosulfate Solution (SPS) solution for bowel preparation prior to colonoscopy and to compare serum sodium levels before and after SPS.

METHODS

This interventional study was conducted at Dr. Ruth K. M. Pfau, Civil Hospital Karachi between June 2019 to November 2019. Patients undergoing colonoscopy were included in the study. All patients were given SPS. Two samples of blood for electrolytes were taken, one 30 minutes before taking SPS solution and another 30 minutes before colonoscopy. Paired sample was used to determine the difference between serum sodium level before taking the colonoscopy solution and serum sodium level before colonoscopy.

RESULTS

Fifty- four patients fulfilling inclusion criteria were included. Out of the 54 patients 28 (51.9%) were males and 26 (48.1%) were females. Mean sodium levels before taking colonoscopy solution was 139.7 ±3.5 mEq/L and mean sodium level before colonoscopy was 138.9 ±3.8 mEq/L. The difference between serum sodium level before taking SPS colonoscopy solution and before colonoscopy was found to be statistically insignificant (t (53) = 1.308; p = 0.196).

CONCLUSION

No serious adverse effects were reported in any of our patients. There was no significant difference in the serum sodium level of patients undergoing colonoscopy before taking SPS bowel preparation solution and serum sodium level before colonoscopy.

摘要

目的

确定在结肠镜检查前服用聚乙二醇硫酸氢钠溶液（SPS）进行肠道准备的患者中低钠血症的发生率，并比较服用SPS前后的血清钠水平。

方法

这项干预性研究于2019年6月至2019年11月在卡拉奇市民医院鲁思·K·M·普法博士医院进行。纳入接受结肠镜检查的患者。所有患者均给予SPS。采集两份血液样本检测电解质，一份在服用SPS溶液前30分钟采集，另一份在结肠镜检查前30分钟采集。采用配对样本检测来确定服用结肠镜检查溶液前的血清钠水平与结肠镜检查前的血清钠水平之间的差异。

结果

纳入了54名符合纳入标准的患者。在这54名患者中，28名（51.9%）为男性，26名（48.1%）为女性。服用结肠镜检查溶液前的平均钠水平为139.7±3.5 mEq/L，结肠镜检查前的平均钠水平为138.9±3.8 mEq/L。服用SPS结肠镜检查溶液前与结肠镜检查前的血清钠水平差异无统计学意义（t(53)=1.308；p=0.196）。