Byrne G E
Cancer Treat Rep. 1977 Sep;61(6):935-44.
The architectural arrangement of the neoplastic cells and their cytologic identification form the histologic basis of the Rappaport classification of non-Hodgkin's lymphomas clinical studies have shown the favorable prognosis of the nodular lymphomas while the diffuse lymphomas irrespective of cell type have a poor prognosis. Several recent studies have shown that pathologists can identify the nodular and diffuse patterns with a high degree of reproducibility. The cytologic subclassification has, however, not achieved a similar high degree of reproducibility. The Southwest Oncology Group study has shown the most reproducible subgroups to be the nodular poorly differentiated lymphocytic malignant lymphoma (ML) and the diffuse histiocytic ML. The clinical significance of the Rappaport classification when applied to childhood lymphomas is not as clear as in adult lymphomas. In view of the recent description of a new clinicopathologic entity primarily in children and adolescents (ie, lymphoblastic ML), IT IS APPARENT THAT THE CHILDHOOD LYMPHOMAS Will have to be examined more critically in order to determine the clinical significance of this classification. Although some have proposed new classifications of these lymphomas based upon immunologic identification of cell origin, none have been shown to be of clinical significance. Based on recent immunologic and clinical studies, a modified classification of the non-Hodgkin's lymphoma is proposed which does not alter its clinical usefulness.
肿瘤细胞的结构排列及其细胞学鉴定构成了拉帕波特非霍奇金淋巴瘤分类的组织学基础。临床研究表明，结节性淋巴瘤预后良好，而弥漫性淋巴瘤无论细胞类型如何，预后都很差。最近的几项研究表明，病理学家能够高度可重复地识别结节性和弥漫性模式。然而，细胞学亚分类尚未达到类似的高可重复性。西南肿瘤学组的研究表明，最具可重复性的亚组是结节性低分化淋巴细胞性恶性淋巴瘤（ML）和弥漫性组织细胞性ML。拉帕波特分类应用于儿童淋巴瘤时的临床意义不如在成人淋巴瘤中那么明确。鉴于最近主要在儿童和青少年中描述了一种新的临床病理实体（即淋巴母细胞性ML），显然必须更严格地检查儿童淋巴瘤，以确定这种分类的临床意义。尽管有些人基于细胞起源的免疫学鉴定提出了这些淋巴瘤的新分类，但尚未证明有临床意义。基于最近的免疫学和临床研究，提出了一种非霍奇金淋巴瘤的改良分类，该分类不会改变其临床实用性。
