Bilateral simultaneous corneal graft rejection--role of tear immunoglobulins.

A report is made on an unusual case of corneal graft which was clear for well over a decade, and then manifested allograft rejection phenomenon concurrently in both eyes initiated by keratoplasty in the second eye. A bilateral and simultaneous corneal graft rejection in an individual does not seem to have been reported previously. Serial tear immunoglobulin (IgG) levels, which were normal in the initial postoperative period, demonstrated an elevation throughout the rejection phenomenon. The possible significance of this rise in the tear IgG levels is discussed.