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[勘误] 三七总皂苷通过调控 PI3K-AKT-mTOR 通路抑制骨关节炎软骨细胞衰老和凋亡

[Corrigendum] Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K‑AKT‑mTOR pathway in osteoarthritic chondrocytes.

机构信息

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

出版信息

Int J Mol Med. 2021 Jan;47(1):408-409. doi: 10.3892/ijmm.2020.4786. Epub 2020 Nov 11.

DOI:10.3892/ijmm.2020.4786
PMID:33236126
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7723677/
Abstract

Following the publication of the above article, the authors have realized that the first author, who analyzed the data, inadvertently made a mistake by over‑estimating the background of the blots in calculating the intensity of the histograms for the western blots shown in Fig. 6A and E. This error led to subsequent differences in the actual quantification and statistics from the originally submitted results. Accordingly, to further verify the conclusions reported in the study, the authors repeated these experiments independently, and the results were found to be consistent with the same changes in trends as originally observed. The revised version of Fig. 6, containing the new western blot data for Fig. 6A and E and new histograms showing the quantification of these data, is shown on the next page. The authors are grateful to the Editor of International Journal of Molecular Medicine for allowing them the opportunity to publish this Corrigendum, and apologize to the readership for any inconvenience caused. [the original article was published in International Journal of Molecular Medicine 45: 1225-1236, 2020; DOI: 10.3892/ijmm.2020.4491].

摘要

在上述文章发表后,作者们意识到,数据分析的第一作者在计算图 6A 和 6E 中的western blot 条带的直方图强度时,不小心犯了一个错误,即高估了条带的背景。这个错误导致后续的实际定量和统计数据与最初提交的结果存在差异。因此,为了进一步验证研究中报告的结论,作者们独立重复了这些实验,结果发现与最初观察到的趋势变化一致。包含图 6A 和 E 的新 western blot 数据以及这些数据的定量新直方图的修订版如图 6 所示,显示在下一页。作者们感谢国际分子医学杂志编辑允许他们发表此勘误,对给读者带来的任何不便表示歉意。[原始文章发表于国际分子医学杂志 45:1225-1236, 2020;DOI: 10.3892/ijmm.2020.4491]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220e/7723677/2734d92af84d/IJMM-47-01-0408-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220e/7723677/2734d92af84d/IJMM-47-01-0408-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220e/7723677/2734d92af84d/IJMM-47-01-0408-g00.jpg

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