Unit of Pediatric Emergency, Department of Adult and Childhood Human Pathology, University Hospital of Messina, Messina, Italy.
Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.
Pediatr Allergy Immunol. 2020 Nov;31 Suppl 26(Suppl 26):63-65. doi: 10.1111/pai.13358.
High-mobility group box 1 (HMGB1) is a nuclear protein involved in DNA replication, transcription, recombination, and repair. In the extracellular space, the HMGB1 plays an essential role in the onset and perpetuation of inflammation, belonging to the group of damage-associated molecular pattern (DAMP) molecules, also called alarmins. For this, HMGB1 has been studied in several acute and chronic inflammatory diseases as an early biomarker of inflammation. An increased concentration of HMGB1 has been detected in serum, as the expression of systemic inflammation, and in specific samples (such as stool, synovial fluid, nasal lavage fluid, sputum, and cerebrospinal fluid), as the expression of local production, in several infectious and/or inflammatory diseases. These data are particularly important because they open new futuristic possibilities for target therapies, potentially also for the COVID-19 treatment.
高迁移率族蛋白 B1（HMGB1）是一种参与 DNA 复制、转录、重组和修复的核蛋白。在细胞外空间，HMGB1 在炎症的发生和持续中起着至关重要的作用，属于损伤相关分子模式（DAMP）分子，也称为警报素。为此，HMGB1 已在几种急性和慢性炎症性疾病中作为炎症的早期生物标志物进行了研究。在几种感染性和/或炎症性疾病中，HMGB1 浓度的增加已在血清中检测到，作为全身炎症的表达，在特定样本（如粪便、滑液、鼻洗液、痰和脑脊液）中作为局部产生的表达。这些数据非常重要，因为它们为靶向治疗开辟了新的未来可能性，可能也为 COVID-19 的治疗开辟了新的未来可能性。
