1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
2Department of Neuroradiology, All India Institute of Medical Sciences, New Delhi, India.
Am J Trop Med Hyg. 2020 Nov 16;104(2):734-738. doi: 10.4269/ajtmh.20-1124.
Antiparasitic treatment improves the prognosis for neurocysticercosis (NCC)-induced seizures. However, patients with high lesion loads are typically denied the possible benefit of cysticidal therapy because of fear of complications, and such patients are not represented in clinical trials involving cysticidal therapy. We provide proof of concept for combination treatment with dual antiparasitic therapy and corticosteroids in patients with diffuse lesions, including starry sky patterns, or calcific NCC. The safety and efficacy of treating patients with high lesion loads or calcific NCC should be tested in a randomized controlled trial.
抗寄生虫治疗可改善脑囊虫病（NCC）引起的癫痫发作的预后。然而，由于担心并发症，通常会拒绝高病变负荷的患者接受杀囊虫治疗，而且临床试验中也不包括接受杀囊虫治疗的此类患者。我们提供了联合应用双抗寄生虫治疗和皮质类固醇治疗弥漫性病变（包括星空模式或钙化性 NCC）患者的概念验证。在随机对照试验中，应测试治疗高病变负荷或钙化性 NCC 患者的安全性和疗效。
