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松木纳米纤维素敷料和细菌纳米纤维素敷料在治疗二度烧伤方面相似吗？大鼠实验研究

PINE NANOCELLULOSE AND BACTERIAL NANOCELLULOSE DRESSINGS ARE SIMILAR IN THE TREATMENT OF SECOND-DEGREE BURN? EXPERIMENTAL STUDY IN RATS.

作者信息

Coelho Guilherme Andrade, MagalhÃes Maria Angélica Baron, Matioski Alysson, Ribas-Filho Jurandir Marcondes, MagalhÃes Washington Luiz Esteves, Claro Francine Ceccon, Ramos Rafael Koerich, Camargo Thayline Mylena Santana de, Malafaia Osvaldo

机构信息

Postgraduate Program in Principles of Surgery, Mackenzie Evangelical Faculty of Paraná/Medical Research Institute, Curitiba, PR, Brazil.

EMBRAPA Forests, Colombo, PR, Brazil.

出版信息

Arq Bras Cir Dig. 2020 Nov 20;33(2):e1533. doi: 10.1590/0102-672020200002e1533. eCollection 2020.

DOI:10.1590/0102-672020200002e1533
PMID:33237169
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7682147/
Abstract

BACKGROUND

Crusts in 7th follow-up day: G1 yes; G2 no; G3 no (left to right). Bespite all the advances in medicine and the wide variety of dressings available, the treatment of burn wounds still represents an important medical challenge. The pinus cellulose membrane dressing is a biomaterial with characteristics similar to those of bacterial cellulose, but with lower cost.

AIM

To evaluate the efficacy of pinus nanocellulose membrane on healing of deep second degree burns in rats and compare with Membracel®.

METHOD

Thirty male Wistar rats were submitted to deep second degree burn in dorse, with boiling water at 97o C for 20 s, generating a 314 mm² area wound. The animals were distributed in three dressing groups (n=10): group 1 - simple gauze; group 2 - bacterial cellulose membrane (Membracel®); and group 3 - pinus cellulose membrane. They were evaluated for 20 days to verify clinical condition, macro and microscopic appearance and wound contraction.

RESULTS

All of them remained clinically well with no differences in weight. Crusts were observed in group 1, and none in groups 2 and 3. Regarding to scar contraction, groups 2 and 3 were similar, better than group 1. Microscopic analysis showed predominance of advanced healing degree in groups 1 and 3, and initial in group 2. Mature collagen was predominant in all groups.

CONCLUSION

The pinus nanocellulose membrane is effective in the treatment of experimental second degree burn in rats and its effectiveness is similar to that of the bacterial nanocellular membrane.

摘要

背景

第7天随访时的痂皮情况：G1有；G2无；G3无（从左至右）。尽管医学取得了诸多进展且有各种各样的敷料可供使用，但烧伤创面的治疗仍然是一项重大的医学挑战。松木纤维素膜敷料是一种生物材料，其特性与细菌纤维素相似，但成本较低。

目的

评估松木纳米纤维素膜对大鼠深二度烧伤愈合的疗效，并与Membracel®进行比较。

方法

30只雄性Wistar大鼠背部用97℃沸水烫伤20秒，形成面积为314mm²的创面。将动物分为三个敷料组（n = 10）：第1组 - 单纯纱布；第2组 - 细菌纤维素膜（Membracel®）；第3组 - 松木纤维素膜。对它们进行20天的评估，以核实临床状况、宏观和微观外观以及创面收缩情况。

结果

所有动物临床状况良好，体重无差异。第1组观察到有痂皮，第2组和第3组无。关于瘢痕收缩，第2组和第3组相似，优于第1组。微观分析显示，第1组和第3组愈合程度以高级为主，第2组以初期为主。所有组均以成熟胶原蛋白为主。

结论

松木纳米纤维素膜对大鼠实验性二度烧伤的治疗有效，其有效性与细菌纳米纤维素膜相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/f830499be081/0102-6720-abcd-33-02-e1533-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/e0af61405d3c/0102-6720-abcd-33-02-e1533-gf1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/e0af61405d3c/0102-6720-abcd-33-02-e1533-gf1a-pt.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/363e89f75c4c/0102-6720-abcd-33-02-e1533-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/2a9e039f0885/0102-6720-abcd-33-02-e1533-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/1b12ae041197/0102-6720-abcd-33-02-e1533-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/f830499be081/0102-6720-abcd-33-02-e1533-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/e0af61405d3c/0102-6720-abcd-33-02-e1533-gf1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/e0af61405d3c/0102-6720-abcd-33-02-e1533-gf1a-pt.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/363e89f75c4c/0102-6720-abcd-33-02-e1533-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/2a9e039f0885/0102-6720-abcd-33-02-e1533-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/1b12ae041197/0102-6720-abcd-33-02-e1533-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab62/7682147/f830499be081/0102-6720-abcd-33-02-e1533-gf4.jpg

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