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西班牙近距离放疗协会和西班牙妇科肿瘤学会阴道穹窿近距离放疗的共识和建议。

Consensus and recommendations on vaginal-cuff Brachytherapy of the Spanish Brachytherapy Groups of SEOR and SEFM.

机构信息

Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, Spain.

Departament de Fonaments Clínics, Universitat de Barcelona, Hospital Clínic Universitari de Barcelona, Barcelona, Spain.

出版信息

Clin Transl Oncol. 2021 Jun;23(6):1193-1200. doi: 10.1007/s12094-020-02510-8. Epub 2020 Nov 25.

DOI:10.1007/s12094-020-02510-8
PMID:33237447
Abstract

PURPOSE/OBJECTIVE(S): On October 5, 2018, a meeting of the Spanish Society of Radiation Oncology (SEOR) Brachytherapy Group was held, in collaboration with the Spanish Society of Medical Physics (SEFM), with the aim of preparing a consensus document on postoperative vaginal-cuff brachytherapy (VCBT).

MATERIALS/METHODS: A survey including 42 questions was sent to Spanish Radiation Oncology Centres before the meeting. The survey items included: experience in VCBT, technique indications, previous patient preparation, applicator type, implant procedure, computerized tomography (CT) simulation, definition of target volumes and organs at risk (OAR), dose prescription, fractionation, treatment planning, dosimetric parameters and constraints to OAR. Thirty-three centres answered the survey. Statistical analysis of the survey considered that there was consensus when there was ≥ 85% of agreement related to a survey item, otherwise an item with < 85% of agreement would be discussed during the meeting to reach consensus.

RESULTS

The results of the survey are reported here. The mean number of patients treated per centre in 2017 was 52 ± 41 (range 7-175), and the mean number of procedures per centre was 175 ± 150 (range 24-701).There was consensus on: the indications, applicator type, the OAR to be considered, the prescription point, standardisation and dosimetric quality parameters. There was no consensus on: patient preparation for the implant, the need for performing CT simulation and the frequency, the length of the vagina to be treated, if CTV should be delimited, the definition of the clinical target volume, fractionation, overall EQD2, active source length, separation between dwelling stepping source positions, if considering the uniformity/maximum values for dwelling stepping sources, the optimization mode, and the limiting doses to the OAR. After presenting the results of the survey, the consensus meeting discussion focused on the issues for which there was no consensus.

CONCLUSION

A consensus document on postoperative VCBT of the Spanish Brachytherapy Groups of SEOR-SEFM was elaborated.

摘要

目的

2018 年 10 月 5 日,西班牙放射肿瘤学会(SEOR)近距离治疗小组与西班牙医学物理学会(SEFM)合作召开了一次会议,旨在制定一份关于术后阴道袖口近距离治疗(VCBT)的共识文件。

材料/方法:在会议之前,向西班牙放射肿瘤学中心发送了一份包含 42 个问题的调查。调查项目包括:VCBT 的经验、技术适应症、患者准备情况、施源器类型、植入程序、计算机断层扫描(CT)模拟、靶区和危及器官(OAR)的定义、剂量处方、分割、治疗计划、剂量学参数和 OAR 限制。33 个中心回答了调查。对调查进行了统计学分析,认为当与调查项目相关的一致性达到≥85%时存在共识,否则在会议期间将对<85%的一致性项目进行讨论以达成共识。

结果

现将调查结果报告如下。2017 年每个中心治疗的患者平均数量为 52±41(范围 7-175),每个中心的手术平均数量为 175±150(范围 24-701)。在以下方面达成共识:适应症、施源器类型、应考虑的 OAR、处方点、标准化和剂量学质量参数。在以下方面未达成共识:植入患者准备、是否需要进行 CT 模拟以及频率、治疗的阴道长度、是否需要划定CTV、临床靶区定义、分割、总 EQD2、有源源长度、驻留步进源位置之间的间隔、是否考虑驻留步进源的均匀性/最大值、优化模式以及 OAR 的限制剂量。在介绍调查结果后,共识会议的讨论重点集中在没有共识的问题上。

结论

制定了西班牙近距离治疗小组 SEOR-SEFM 的术后 VCBT 共识文件。

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Long-term outcome and quality of life of patients with endometrial carcinoma treated with or without pelvic radiotherapy in the post operative radiation therapy in endometrial carcinoma 1 (PORTEC-1) trial.PORTEC-1 试验中手术后放疗的子宫内膜癌 1 期(PORTEC-1)试验中,接受或不接受盆腔放疗的子宫内膜癌患者的长期结果和生活质量。
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