Department of Pathology, King George's Medical University, Lucknow, India.
Department of Radiation Oncology, King George's Medical University, Lucknow, India.
Diagn Cytopathol. 2021 Feb;49(2):E60-E64. doi: 10.1002/dc.24581. Epub 2020 Aug 15.
Mucoepidermoid carcinoma is the most common malignant salivary gland neoplasm comprising approximately 10% of all tumours of the major salivary gland. Owing to a plethora of morphological variations, it poses a diagnostic challenge on fine-needle aspiration cytology. Oncocytic variant of mucoepidermoid carcinoma is a rare subtype seen in the age group of 20-80 years. It is crucial to make the correct diagnosis on cytology as it has therapeutic implications. Oncocytes can be present in a wide range of salivary gland lesions ranging from non-neoplastic conditions to benign and malignant lesions. We report a case of oncocytic mucoepidermoid carcinoma of the parotid gland in a 12-year-old boy which is the youngest age reported for the same. On cytology, this case was initially diagnosed as Warthin's tumour and was supported by radiology. However, histomorphological findings clinched the diagnosis of an oncocytic variant of mucoepidermoid carcinoma with the aid of immunohistochemistry.
黏液表皮样癌是最常见的恶性涎腺肿瘤,约占大涎腺肿瘤的 10%。由于存在大量的形态学变异,它在细针抽吸细胞学检查中构成了诊断挑战。涎腺的嗜酸细胞型黏液表皮样癌是一种罕见的亚型,见于 20-80 岁年龄组。在细胞学上做出正确的诊断很重要,因为它具有治疗意义。嗜酸细胞可以存在于广泛的涎腺病变中,从非肿瘤性疾病到良性和恶性病变。我们报告了一例发生在 12 岁男孩腮腺的嗜酸细胞型黏液表皮样癌,这是报道的同类型中年龄最小的病例。在细胞学上,该病例最初被诊断为沃辛瘤,并得到影像学的支持。然而,组织形态学发现借助免疫组织化学证实了嗜酸细胞型黏液表皮样癌的诊断。