Cisarovsky Christophe, Kraege Vanessa, Obeid Michel, Garnier Antoine
Service de médecine interne, Département de médecine interne, CHUV, 1011 Lausanne.
Service d'immunologie et allergie, Département de médecine interne, CHUV, 1011 Lausanne.
Rev Med Suisse. 2020 Nov 25;16(716):2264-2270.
Immune checkpoint inhibitors have radically changed oncology by significantly improving prognosis and survival of many patients, even at an advanced or metastatic stage. Some patients undergoing immunotherapy develop adverse immune-related events, presenting a toxicity spectrum that can affect any organ, separately or simultaneously, with different intensities depending on the treatment used and patient characteristics. We hereby suggest a diagnostic and therapeutic approach that any internist, general practitioner or emergency doctor should have facing digestive, cardiac and pulmonary toxicities.
免疫检查点抑制剂已彻底改变了肿瘤学，显著改善了许多患者的预后和生存率，即使是在晚期或转移阶段。一些接受免疫治疗的患者会出现不良免疫相关事件，其毒性谱可单独或同时影响任何器官，毒性强度因所使用的治疗方法和患者特征而异。在此，我们提出一种诊断和治疗方法，任何内科医生、全科医生或急诊医生在面对消化、心脏和肺部毒性时都应掌握。
