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[年龄相关性脑小血管病合并特发性正常压力脑积水的影像学特征分析]

[Analysis of imaging features of age-related cerebral small vessel disease with idiopathic normal pressure hydrocephalus].

作者信息

Liu S X, Song K Y, Li Y, Chen X D, Men X J, Lu T T, Huang X H, Lu Z Z, Wu A M

机构信息

Department of Neurology, Psychological and Neurological Diseases Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2020 Nov 24;100(43):3402-3406. doi: 10.3760/cma.j.cn112137-20200615-01853.

Abstract

To explore the imaging features in age-related cerebral small vessel disease (ArCSVD) with idiopathic normal pressure hydrocephalus (INPH). Ten cases of age-related cerebral small vessel disease (CSVD) with idiopathic normal pressure hydrocephalus admitted to the Third Affiliated Hospital of Sun Yat-sen University from December 2015 to March 2020 were retrospective analyzed, all patients met the inclusion and exclusion criteria, and completed the head Magnetic resonance angiography plain scan, T2 fluid attenuated inversion recovery and Susceptibility Weighted Imaging sequence. Deep marrow venous signs (DMVs), INPH severity (DESH score), cortical/subcortical and deep microhemorrhages (CMBs) statistics, paraventricular and deep white matter damage (WMH) severity and CSVD imaging burden score were acquired, and correlations of DMVs and DESH scores with CMBs, WMH and Burden scores were evaluated using Spearman correlation analysis. DMVs and DESH scores were significantly and positively correlated (=0.965 9, 0.000 1). DMVs and DESH scores were not significantly correlated with cortical/subcortical CMBs and deep CMBs. Likewise, DMVs and DESH scores were not significantly correlated with deep WMH. The WMH score of paraventricular of the 10 cases was 3 points, and the Burden score was 4 points. DMVs may be an indicator of the severity of ArCSVD with INPH, due to the small sample size of the current study, more cases are needed for further verification.

摘要

探讨伴特发性正常压力脑积水(INPH)的年龄相关性脑小血管病(ArCSVD)的影像学特征。回顾性分析2015年12月至2020年3月中山大学附属第三医院收治的10例伴特发性正常压力脑积水的年龄相关性脑小血管病(CSVD)患者,所有患者均符合纳入和排除标准,并完成头部磁共振血管造影平扫、T2液体衰减反转恢复序列和磁敏感加权成像序列。获取深部髓静脉征(DMVs)、INPH严重程度(DESH评分)、皮质/皮质下及深部微出血(CMBs)统计数据、脑室旁和深部白质损伤(WMH)严重程度及CSVD影像学负担评分,并采用Spearman相关性分析评估DMVs和DESH评分与CMBs、WMH及负担评分的相关性。DMVs与DESH评分呈显著正相关(r = 0.965 9,P = 0.000 1)。DMVs和DESH评分与皮质/皮质下CMBs及深部CMBs无显著相关性。同样,DMVs和DESH评分与深部WMH也无显著相关性。10例患者脑室旁白质高信号评分为3分,负担评分为4分。DMVs可能是伴INPH的ArCSVD严重程度的一个指标,由于本研究样本量较小,需要更多病例进一步验证。

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