中国西藏拉萨儿童斜视的患病率及相关危险因素：一项基于学校的横断面研究。
Prevalence and associated risk factors for childhood strabismus in Lhasa, Tibet, China: a cross-sectional, school-based study.
作者信息
He Hailong, Fu Jing, Meng Zhaojun, Chen Weiwei, Li Lei, Zhao Xinyu
机构信息
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, No.1, Dong Jiao Min Xiang Street, Dongcheng District, Beijing, 100730, China.
Beijing Institute of Ophthalmology, Beijing, China.
出版信息
BMC Ophthalmol. 2020 Nov 25;20(1):463. doi: 10.1186/s12886-020-01732-2.
BACKGROUND
To estimate the prevalence of strabismus and associated risk factors among grade one school children in Lhasa, Tibet, China.
METHODS
The Lhasa Childhood Eye Study (LCES) was a cross-sectional, school-based childhood study conducted in Grade one students from primary schools in Lhasa, Tibet, China. Comprehensive ophthalmic examinations and basic systemic examinations were evaluated. A questionnaire survey containing information about children, as well as parents' information, was sent to the corresponding parents of eligible children. The prevalence of strabismus and its 95% confidence interval was estimated. Univariate and multivariate logistic regression analyses were conducted to determine the associated risk factors.
RESULTS
A total of 1942 eligible grade one students were enrolled, of which 1856 participants completed all examinations. The average age was 6.83 ± 0.46 years, 53% of participants were boys and 1762 were the Tibetan Minority. Over all, the prevalence of strabismus was 68/1856 (3.7%) (95%CI: 2.81,4.52), with no difference between the ages, genders, ethnicities and body mass index, while tilting one's head when writing may be a risk factor for strabismus (P = 0.004). Strabismus students had mean best corrected visual acuity of 0.16 ± 0.28(LogMAR), over 50% patients with esotropia were hyperopic, and participants who had stereopsis impairments showed a significant difference between esotropia and exotropia (P = 0.026).
CONCLUSIONS
The prevalence of strabismus in LCES was 3.7%, which is higher than previous reports from Chinese childhood epidemiology studies. Strabismus is a common contributing factor to amblyopia. Tilting one's head when writing may be a risk factor. Esotropia is more likely to affect stereopsis and be associated with the refractive state of hyperopia.
TRIAL REGISTRATION
The study has finished the clinical registration on Chinese Clinical Trial Registry. ( http://www.chictr.org.cn , ChiCTR1900026693 ).
背景
评估中国西藏拉萨市一年级小学生斜视的患病率及其相关危险因素。
方法
拉萨儿童眼病研究（LCES）是一项基于学校的横断面儿童研究，研究对象为中国西藏拉萨市小学一年级学生。对其进行了全面的眼科检查和基本的全身检查。向符合条件儿童的相应家长发送了一份包含儿童信息以及家长信息的问卷调查。估计斜视的患病率及其95%置信区间。进行单因素和多因素逻辑回归分析以确定相关危险因素。
结果
共纳入1942名符合条件的一年级学生，其中1856名参与者完成了所有检查。平均年龄为6.83±0.46岁，53%的参与者为男孩，1762人为藏族。总体而言，斜视患病率为68/1856（3.7%）（95%CI：2.81，4.52），在年龄、性别、种族和体重指数之间无差异，而写字时歪头可能是斜视的一个危险因素（P = 0.004）。斜视学生的最佳矫正视力平均为0.16±0.28（LogMAR），超过50%的内斜视患者为远视，有立体视功能障碍的参与者在内斜视和外斜视之间存在显著差异（P = 0.026）。
结论
LCES中斜视的患病率为3.7%，高于中国儿童流行病学研究先前的报告。斜视是导致弱视的常见因素。写字时歪头可能是一个危险因素。内斜视更易影响立体视，并与远视屈光状态有关。
试验注册
该研究已在中国临床试验注册中心完成临床注册。（http://www.chictr.org.cn，ChiCTR1900026693）
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